KUMAMOTO University

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研究業績RESEARCH ACHIEVEMENTS

  1. Amano M, Tojo Y, Salcedo-Gómez PM, Parham GL, Nyalapatla PR, Das D, Ghosh AK, Mitsuya H.

    A novel tricyclic ligand-containing nonpeptidic HIV-1 protease inhibitor, GRL-0739, effectively inhibits the replication of multidrug-resistant HIV-1 variants and has a desirable central nervous system penetration property in vitro.

    Antimicrob Agents Chemother. 2015 May;59(5):2625-35. doi: 10.1128/AAC.04757-14. Epub 2015 Feb 17. PMID: 25691652; PMCID: PMC4394833.

    https://pubmed.ncbi.nlm.nih.gov/25691652/

  2. Okazaki S, Oishi S, Mizuhara T, Shimura K, Murayama H, Ohno H, Matsuoka M, Fujii N.

    Investigations of possible prodrug structures for 2-(2-mercaptophenyl)tetrahydropyrimidines: reductive conversion from anti-HIV agents with pyrimidobenzothiazine and isothiazolopyrimidine scaffolds.

    Org Biomol Chem. 2015 Apr 28;13(16):4706-13. doi: 10.1039/c5ob00301f. PMID: 25800792.

    https://pubmed.ncbi.nlm.nih.gov/25800792/

  3. Fujiwara S, Wada N, Kawano Y, Okuno Y, Kikukawa Y, Endo S, Nishimura N, Ueno N, Mitsuya H, Hata H.

    Lactate, a putative survival factor for myeloma cells, is incorporated by myeloma cells through monocarboxylate transporters 1.

    Exp Hematol Oncol. 2015 Apr 21;4:12. doi: 10.1186/s40164-015-0008-z. PMID: 25909034; PMCID: PMC4407384.

    https://pubmed.ncbi.nlm.nih.gov/25909034/

  4. Furuta RA, Ma G, Matsuoka M, Otani S, Matsukura H, Hirayama F.

    Reevaluation of confirmatory tests for human T-cell leukemia virus Type 1 using a luciferase immunoprecipitation system in blood donors.

    Transfusion. 2015 Apr;55(4):880-9. doi: 10.1111/trf.12911. Epub 2014 Nov 2. PMID: 25363675.

    https://pubmed.ncbi.nlm.nih.gov/25363675/

  5. Okazaki S, Mizuhara T, Shimura K, Murayama H, Ohno H, Oishi S, Matsuoka M, Fujii N.

    Identification of anti-HIV agents with a novel benzo[4,5]isothiazolo[2,3-a]pyrimidine scaffold.

    Bioorg Med Chem. 2015 Apr 1;23(7):1447-52. doi: 10.1016/j.bmc.2015.02.015. Epub 2015 Feb 16. PMID: 25744188.

    https://pubmed.ncbi.nlm.nih.gov/25744188/

  6. Takachi T, Takahashi M, Takahashi-Yoshita M, Higuchi M, Obata M, Mishima Y, Okuda S, Tanaka Y, Matsuoka M, Saitoh A, Green PL, Fujii M.

    Human T-cell leukemia virus type 1 Tax oncoprotein represses the expression of the BCL11B tumor suppressor in T-cells.

    Cancer Sci. 2015 Apr;106(4):461-5. doi: 10.1111/cas.12618. Epub 2015 Mar 16. PMID: 25613934; PMCID: PMC4409891.

    https://pubmed.ncbi.nlm.nih.gov/25613934/

  7. Das D, Maeda K, Hayashi Y, Gavande N, Desai DV, Chang SB, Ghosh AK, Mitsuya H.

    Insights into the mechanism of inhibition of CXCR4: identification of Piperidinylethanamine analogs as anti-HIV-1 inhibitors.

    Antimicrob Agents Chemother. 2015 Apr;59(4):1895-904. doi: 10.1128/AAC.04654-14. Epub 2015 Jan 12. PMID: 25583709; PMCID: PMC4356787.

    https://pubmed.ncbi.nlm.nih.gov/25583709/

  8. Wada N, Kawano Y, Fujiwara S, Kikukawa Y, Okuno Y, Tasaki M, Ueda M, Ando Y, Yoshinaga K, Ri M, Iida S, Nakashima T, Shiotsu Y, Mitsuya H, Hata H.

    Shikonin, dually functions as a proteasome inhibitor and a necroptosis inducer in multiple myeloma cells.

    Int J Oncol. 2015 Mar;46(3):963-72. doi: 10.3892/ijo.2014.2804. Epub 2014 Dec 19. PMID: 25530098; PMCID: PMC4324584.

    https://pubmed.ncbi.nlm.nih.gov/25530098/

  9. Haji S, Abe Y, Tsuda M, Toyoda K, Choi I, Suehiro Y, Shiratsuchi M, Kiyasu J, Uike N.

    [CD20-positive plasma cell myeloma with lymphoplasmacytoid appearance mimicking low-grade B-cell lymphoma].

    Rinsho Ketsueki. 2015 Mar;56(3):335-8. Japanese. doi: 10.11406/rinketsu.56.335. PMID: 25876789.

    https://pubmed.ncbi.nlm.nih.gov/25876789/

  10. Ma G, Yasunaga J, Akari H, Matsuoka M.

    TCF1 and LEF1 act as T-cell intrinsic HTLV-1 antagonists by targeting Tax.

    Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2216-21. doi: 10.1073/pnas.1419198112. Epub 2015 Feb 2. PMID: 25646419; PMCID: PMC4343127.

    https://pubmed.ncbi.nlm.nih.gov/25646419/

  11. Kikukawa Y, Yuki H, Hirata S, Ide K, Nakata H, Miyakawa T, Matsuno N, Nosaka K, Yonemura Y, Kawaguchi T, Hata H, Mitsuya H, Okuno Y.

    Combined use of bortezomib, cyclophosphamide, and dexamethasone induces favorable hematological and organ responses in Japanese patients with amyloid light-chain amyloidosis: a single-institution retrospective study.

    Int J Hematol. 2015 Feb;101(2):133-9. doi: 10.1007/s12185-014-1705-9. Epub 2014 Nov 28. PMID: 25430082.

    https://pubmed.ncbi.nlm.nih.gov/25430082/

  12. Ghosh AK, Yashchuk S, Mizuno A, Chakraborty N, Agniswamy J, Wang YF, Aoki M, Gomez PM, Amano M, Weber IT, Mitsuya H.

    Design of gem-difluoro-bis-tetrahydrofuran as P2 ligand for HIV-1 protease inhibitors to improve brain penetration: synthesis, X-ray studies, and biological evaluation.

    ChemMedChem. 2015 Jan;10(1):107-15. doi: 10.1002/cmdc.201402358. Epub 2014 Oct 21. PMID: 25336073; PMCID: PMC4419590.

    https://pubmed.ncbi.nlm.nih.gov/25336073/

  13. Kikukawa Y, Yamamura-Fujimoto A, Endo S, Miyagawa E, Kawano Y, Ueno S, Mitsuya H, Hata H, Okuno Y.

    Successful Treatment of Bing-Neel Syndrome Accompanying Waldenström’s Macroglobulinemia with R-MPV: A Case Report.

    J Clin Exp Hematop. 2015;55(2):113-9. doi: 10.3960/jslrt.55.113. PMID: 26490525.

    https://pubmed.ncbi.nlm.nih.gov/26490525/

  14. Hirano T, Higuchi Y, Yuki H, Hirata S, Nosaka K, Ishii N, Hashimoto T, Mitsuya H, Okuno Y.

    Rituximab Monotherapy and Rituximab-Containing Chemotherapy Were Effective for Paraneoplastic Pemphigus Accompanying Follicular Lymphoma, but not for Subsequent Bronchiolitis Obliterans.

    J Clin Exp Hematop. 2015;55(2):83-8. doi: 10.3960/jslrt.55.83. PMID: 26490520.

    https://pubmed.ncbi.nlm.nih.gov/26490520/

  15. Imoto S, Kohgo S, Tokuda R, Kumamoto H, Aoki M, Amano M, Kuwata-Higashi N, Mitsuya H, Haraguchi K.

    Design, Synthesis, and Evaluation of Anti-HBV Activity of Hybrid Molecules of Entecavir and Adefovir: Exomethylene Acycloguanine Nucleosides and Their Monophosphate Derivatives.

    Nucleosides Nucleotides Nucleic Acids. 2015;34(8):590-602. doi: 10.1080/15257770.2015.1037456. PMID: 26167667.

    https://pubmed.ncbi.nlm.nih.gov/26167667/

  16. Miyazaki Y, Taguchi K, Sou K, Watanabe H, Ishima Y, Miyakawa T, Mitsuya H, Fukagawa M, Otagiri M, Maruyama T.

    Therapeutic impact of erythropoietin-encapsulated liposomes targeted to bone marrow on renal anemia.

    Mol Pharm. 2014 Nov 3;11(11):4238-48. doi: 10.1021/mp500453a. Epub 2014 Oct 6. PMID: 25255196.

    https://pubmed.ncbi.nlm.nih.gov/25255196/

  17. Lavorgna A, Matsuoka M, Harhaj EW.

    A critical role for IL-17RB signaling in HTLV-1 tax-induced NF-κB activation and T-cell transformation.

    PLoS Pathog. 2014 Oct 23;10(10):e1004418. doi: 10.1371/journal.ppat.1004418. PMID: 25340344; PMCID: PMC4207800.

    https://pubmed.ncbi.nlm.nih.gov/25340344/

  18. Uike N, Choi I, Tsuda M, Haji S, Toyoda K, Suehiro Y, Abe Y, Hayashi T, Sawamoto H, Kaneko K, Shimokawa M, Nakagawa M.

    Factors associated with effects of 90Y-ibritumomab tiuxetan in patients with relapsed or refractory low-grade B cell non-Hodgkin lymphoma: single-institution experience with 94 Japanese patients in rituximab era.

    Int J Hematol. 2014 Oct;100(4):386-92. doi: 10.1007/s12185-014-1636-5. Epub 2014 Aug 21. PMID: 25142378.

    https://pubmed.ncbi.nlm.nih.gov/25142378/

  19. Niederer HA, Laydon DJ, Melamed A, Elemans M, Asquith B, Matsuoka M, Bangham CR.

    HTLV-1 proviral integration sites differ between asymptomatic carriers and patients with HAM/TSP.

    Virol J. 2014 Sep 30;11:172. doi: 10.1186/1743-422X-11-172. PMID: 25270762; PMCID: PMC4192323.

    https://pubmed.ncbi.nlm.nih.gov/25270762/

  20. Ghosh AK, Schiltz GE, Rusere LN, Osswald HL, Walters DE, Amano M, Mitsuya H.

    Design and synthesis of potent macrocyclic HIV-1 protease inhibitors involving P1-P2 ligands.

    Org Biomol Chem. 2014 Sep 21;12(35):6842-54. doi: 10.1039/c4ob00738g. PMID: 25050776; PMCID: PMC4133278.

    https://pubmed.ncbi.nlm.nih.gov/25050776/

  21. Michailidis E, Huber AD, Ryan EM, Ong YT, Leslie MD, Matzek KB, Singh K, Marchand B, Hagedorn AN, Kirby KA, Rohan LC, Kodama EN, Mitsuya H, Parniak MA, Sarafianos SG.

    4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) inhibits HIV-1 reverse transcriptase with multiple mechanisms.

    J Biol Chem. 2014 Aug 29;289(35):24533-48. doi: 10.1074/jbc.M114.562694. Epub 2014 Jun 26. PMID: 24970894; PMCID: PMC4148878.

    https://pubmed.ncbi.nlm.nih.gov/24970894/

  22. Hayashi H, Takamune N, Nirasawa T, Aoki M, Morishita Y, Das D, Koh Y, Ghosh AK, Misumi S, Mitsuya H.

    Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir.

    Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12234-9. doi: 10.1073/pnas.1400027111. Epub 2014 Aug 4. PMID: 25092296; PMCID: PMC4142999.

    https://pubmed.ncbi.nlm.nih.gov/25092296/

  23. Zhang W, Parniak MA, Mitsuya H, Sarafianos SG, Graebing PW, Rohan LC.

    Preformulation studies of EFdA, a novel nucleoside reverse transcriptase inhibitor for HIV prevention.

    Drug Dev Ind Pharm. 2014 Aug;40(8):1101-11. doi: 10.3109/03639045.2013.809535. Epub 2013 Jul 10. PMID: 23841536; PMCID: PMC4136418.

    https://pubmed.ncbi.nlm.nih.gov/23841536/

  24. Maie K, Fuji S, Tajima K, Tatsuno M, Yamagata S, Takahashi N, Ueda R, Hashimoto H, Takano K, Inoue Y, Ito A, Hayashi Y, Okinaka K, Kurosawa S, Kim SW, Tanosaki R, Heike Y, Yamashita T, Fukuda T.

    A higher number of infused CD34(+) cells has a positive impact on the clinical outcome after related PBSC transplantation.

    Bone Marrow Transplant. 2014 Aug;49(8):1113-5. doi: 10.1038/bmt.2014.94. Epub 2014 May 5. PMID: 24797181.

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