KUMAMOTO University

R

研究業績RESEARCH ACHIEVEMENTS

  1. Yasuma K, Matsuzaki T, Yamano Y, Takashima H, Matsuoka M, Saito M.

    HTLV-1 subgroups associated with the risk of HAM/TSP are related to viral and host gene expression in peripheral blood mononuclear cells, independent of the transactivation functions of the viral factors.

    J Neurovirol. 2016 Aug;22(4):416-30. doi: 10.1007/s13365-015-0407-2. Epub 2015 Dec 3. PMID: 26635027.

    https://pubmed.ncbi.nlm.nih.gov/26635027/

  2. Ghosh AK, Osswald HL, Glauninger K, Agniswamy J, Wang YF, Hayashi H, Aoki M, Weber IT, Mitsuya H.

    Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV-1 Protease Inhibitors: Design, Synthesis, Protein X-ray Structural Studies, and Biological Evaluation.

    J Med Chem. 2016 Jul 28;59(14):6826-37. doi: 10.1021/acs.jmedchem.6b00639. Epub 2016 Jul 7. PMID: 27389367; PMCID: PMC5360270.

    https://pubmed.ncbi.nlm.nih.gov/27389367/

  3. Manier S, Kawano Y, Bianchi G, Roccaro AM, Ghobrial IM.

    Cell autonomous and microenvironmental regulation of tumor progression in precursor states of multiple myeloma.

    Curr Opin Hematol. 2016 Jul;23(4):426-33. doi: 10.1097/MOH.0000000000000259. PMID: 27101529.

    https://pubmed.ncbi.nlm.nih.gov/27101529/

  4. Sugata K, Yasunaga J, Miura M, Akari H, Utsunomiya A, Nosaka K, Watanabe Y, Suzushima H, Koh KR, Nakagawa M, Kohara M, Matsuoka M.

    Enhancement of anti-STLV-1/HTLV-1 immune responses through multimodal effects of anti-CCR4 antibody.

    Sci Rep. 2016 Jun 2;6:27150. doi: 10.1038/srep27150. PMID: 27250643; PMCID: PMC4890010.

    https://pubmed.ncbi.nlm.nih.gov/27250643/

  5. Fujiwara S, Mochinaga H, Nakata H, Ohshima K, Matsumoto M, Uchiba M, Mikami Y, Hata H, Okuno Y, Mitsuya H, Nosaka K.

    Successful treatment of TAFRO syndrome, a variant type of multicentric Castleman disease with thrombotic microangiopathy, with anti-IL-6 receptor antibody and steroids.

    Int J Hematol. 2016 Jun;103(6):718-23. doi: 10.1007/s12185-016-1978-2. Epub 2016 Mar 15. PMID: 26980221.

    https://pubmed.ncbi.nlm.nih.gov/26980221/

  6. Higuchi Y, Tokunaga K, Watanabe Y, Kawakita T, Harada N, Yamaguchi S, Nosaka K, Mitsuya H, Asou N.

    Lineage switch with t(6;11)(q27;q23) from T-cell lymphoblastic lymphoma to acute monoblastic leukemia at relapse.

    Cancer Genet. 2016 Jun;209(6):267-71. doi: 10.1016/j.cancergen.2016.05.070. Epub 2016 May 18. PMID: 27268298.

    https://pubmed.ncbi.nlm.nih.gov/27268298/

  7. Roccaro AM, Sacco A, Shi J, Chiarini M, Perilla-Glen A, Manier S, Glavey S, Aljawai Y, Mishima Y, Kawano Y, Moschetta M, Correll M, Improgo MR, Brown JR, Imberti L, Rossi G, Castillo JJ, Treon SP, Freedman ML, Van Allen EM, Hide W, Hiller E, Rainville I, Ghobrial IM.

    Exome sequencing reveals recurrent germ line variants in patients with familial Waldenström macroglobulinemia.

    Blood. 2016 May 26;127(21):2598-606. doi: 10.1182/blood-2015-11-680199. Epub 2016 Feb 22. PMID: 26903547.

    https://pubmed.ncbi.nlm.nih.gov/26903547/

  8. Moschetta M, Mishima Y, Kawano Y, Manier S, Paiva B, Palomera L, Aljawai Y, Calcinotto A, Unitt C, Sahin I, Sacco A, Glavey S, Shi J, Reagan MR, Prosper F, Bellone M, Chesi M, Bergsagel LP, Vacca A, Roccaro AM, Ghobrial IM.

    Targeting vasculogenesis to prevent progression in multiple myeloma.

    Leukemia. 2016 May;30(5):1103-15. doi: 10.1038/leu.2016.3. Epub 2016 Feb 3. PMID: 26859080.

    https://pubmed.ncbi.nlm.nih.gov/26859080/

  9. Inoue Y, Fuji S, Tanosaki R, Fukuda T.

    Pretransplant mogamulizumab against ATLL might increase the risk of acute GVHD and non-relapse mortality.

    Bone Marrow Transplant. 2016 May;51(5):725-7. doi: 10.1038/bmt.2015.315. Epub 2015 Dec 21. PMID: 26691420.

    https://pubmed.ncbi.nlm.nih.gov/26691420/

  10. Tanaka Y, Kurosawa S, Tajima K, Tanaka T, Ito R, Inoue Y, Okinaka K, Inamoto Y, Fuji S, Kim SW, Tanosaki R, Yamashita T, Fukuda T.

    Analysis of non-relapse mortality and causes of death over 15 years following allogeneic hematopoietic stem cell transplantation.

    Bone Marrow Transplant. 2016 Apr;51(4):553-9. doi: 10.1038/bmt.2015.330. Epub 2016 Jan 11. PMID: 26752142.

    https://pubmed.ncbi.nlm.nih.gov/26752142/

  11. Kuriyama K, Fuji S, Inamoto Y, Tajima K, Tanaka T, Inoue Y, Ito R, Hayashi Y, Ito A, Kurosawa S, Kim SW, Yamashita T, Fukuda T.

    Impact of low-dose rabbit anti-thymocyte globulin in unrelated hematopoietic stem cell transplantation.

    Int J Hematol. 2016 Apr;103(4):453-60. doi: 10.1007/s12185-016-1947-9. Epub 2016 Feb 9. PMID: 26857285.

    https://pubmed.ncbi.nlm.nih.gov/26857285/

  12. Kumamoto H, Fukano M, Nakano T, Iwagami K, Takeyama C, Kohgo S, Imoto S, Amano M, Kuwata-Higashi N, Aoki M, Abe H, Mitsuya H, Fukuhara K, Haraguchi K.

    Diastereoselective Synthesis of 6″-(Z)- and 6″-(E)-Fluoro Analogues of Anti-hepatitis B Virus Agent Entecavir and Its Evaluation of the Activity and Toxicity Profile of the Diastereomers.

    J Org Chem. 2016 Apr 1;81(7):2827-36. doi: 10.1021/acs.joc.6b00105. Epub 2016 Mar 24. PMID: 27009432.

    https://pubmed.ncbi.nlm.nih.gov/27009432/

  13. Haji S, Kiyasu J, Choi I, Suehiro Y, Toyoda K, Tsuda M, Takamatsu A, Nakashima Y, Miyoshi H, Shiratsuchi M, Yamasaki S, Uike N, Abe Y.

    Administration of an anti-CC chemokine receptor 4 monoclonal antibody, mogamulizumab, before allogeneic bone marrow transplantation for adult T-cell leukemia/lymphoma.

    Bone Marrow Transplant. 2016 Mar;51(3):432-4. doi: 10.1038/bmt.2015.254. Epub 2015 Nov 2. PMID: 26524267.

    https://pubmed.ncbi.nlm.nih.gov/26524267/

  14. Doi M, Murai I, Kunisue S, Setsu G, Uchio N, Tanaka R, Kobayashi S, Shimatani H, Hayashi H, Chao HW, Nakagawa Y, Takahashi Y, Hotta Y, Yasunaga J, Matsuoka M, Hastings MH, Kiyonari H, Okamura H.

    Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour.

    Nat Commun. 2016 Feb 17;7:10583. doi: 10.1038/ncomms10583. PMID: 26882873; PMCID: PMC4757782.

    https://pubmed.ncbi.nlm.nih.gov/26882873/

  15. Fuji S, Fujiwara H, Nakano N, Wake A, Inoue Y, Fukuda T, Hidaka M, Moriuchi Y, Miyamoto T, Uike N, Taguchi J, Eto T, Tomoyose T, Kondo T, Yamanoha A, Ichinohe T, Atsuta Y, Utsunomiya A; ATL Working Group of the Japan Society for Hematopoietic Cell Transplantation.

    Early application of related SCT might improve clinical outcome in adult T-cell leukemia/lymphoma.

    Bone Marrow Transplant. 2016 Feb;51(2):205-11. doi: 10.1038/bmt.2015.265. Epub 2015 Nov 2. PMID: 26524263.

    https://pubmed.ncbi.nlm.nih.gov/26524263/

  16. Endo S, Amano M, Nishimura N, Ueno N, Ueno S, Yuki H, Fujiwara S, Wada N, Hirata S, Hata H, Mitsuya H, Okuno Y.

    Immunomodulatory drugs act as inhibitors of DNA methyltransferases and induce PU.1 up-regulation in myeloma cells.

    Biochem Biophys Res Commun. 2016 Jan 8;469(2):236-42. doi: 10.1016/j.bbrc.2015.11.116. Epub 2015 Nov 30. PMID: 26657848.

    https://pubmed.ncbi.nlm.nih.gov/26657848/

  17. Yasuma K, Yasunaga J, Takemoto K, Sugata K, Mitobe Y, Takenouchi N, Nakagawa M, Suzuki Y, Matsuoka M.

    HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT).

    PLoS Pathog. 2016 Jan 6;12(1):e1005372. doi: 10.1371/journal.ppat.1005372. PMID: 26735971; PMCID: PMC4703212.

    https://pubmed.ncbi.nlm.nih.gov/26735971/

  18. Glavey SV, Manier S, Sacco A, Salem K, Kawano Y, Bouyssou J, Ghobrial IM, Roccaro AM.

    Epigenetics in Multiple Myeloma.

    Cancer Treat Res. 2016;169:35-49. doi: 10.1007/978-3-319-40320-5_4. PMID: 27696257.

  19. Moschetta M, Kawano Y, Podar K.

    Targeting the Bone Marrow Microenvironment.

    Cancer Treat Res. 2016;169:63-102. doi: 10.1007/978-3-319-40320-5_6. PMID: 27696259.

  20. Makita S, Fuji S, Takano K, Tanaka T, Inoue Y, Ito R, Ito A, Hayashi Y, Tajima K, Okinaka K, Kurosawa S, Kim SW, Yamashita T, Tanosaki R, Tobinai K, Fukuda T.

    Clinical Outcomes after Allogeneic Stem Cell Transplantation for Adult Lymphoblastic Lymphoma.

    J Clin Exp Hematop. 2016;56(1):28-33. doi: 10.3960/jslrt.56.28. PMID: 27334855; PMCID: PMC6144282.

    https://pubmed.ncbi.nlm.nih.gov/27334855/

  21. Kikukawa Y, Hata H, Ueda M, Yamashita T, Nasu S, Ide K, Ueno S, Ando Y, Mitsuya H, Okuno Y.

    Successful Treatment of Amyloid Light-chain Amyloidosis in a Charcot-Marie-Tooth Disease Patient with Lenalidomide, Cyclophosphamide, and Dexamethasone.

    Intern Med. 2016;55(18):2707-12. doi: 10.2169/internalmedicine.55.5815. Epub 2016 Sep 15. PMID: 27629972.

    https://pubmed.ncbi.nlm.nih.gov/27629972/

  22. Ghosh AK, Martyr CD, Kassekert LA, Nyalapatla PR, Steffey M, Agniswamy J, Wang YF, Weber IT, Amano M, Mitsuya H.

    Design, synthesis, biological evaluation and X-ray structural studies of HIV-1 protease inhibitors containing substituted fused-tetrahydropyranyl tetrahydrofuran as P2-ligands.

    Org Biomol Chem. 2015 Dec 28;13(48):11607-21. doi: 10.1039/c5ob01930c. Epub 2015 Oct 14. PMID: 26462551; PMCID: PMC4666783.

    https://pubmed.ncbi.nlm.nih.gov/26462551/

  23. Aoki M, Hayashi H, Yedidi RS, Martyr CD, Takamatsu Y, Aoki-Ogata H, Nakamura T, Nakata H, Das D, Yamagata Y, Ghosh AK, Mitsuya H.

    C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir.

    J Virol. 2015 Nov 18;90(5):2180-94. doi: 10.1128/JVI.01829-15. PMID: 26581995; PMCID: PMC4810716.

    https://pubmed.ncbi.nlm.nih.gov/26581995/

  24. Kataoka K, Nagata Y, Kitanaka A, Shiraishi Y, Shimamura T, Yasunaga J, Totoki Y, Chiba K, Sato-Otsubo A, Nagae G, Ishii R, Muto S, Kotani S, Watatani Y, Takeda J, Sanada M, Tanaka H, Suzuki H, Sato Y, Shiozawa Y, Yoshizato T, Yoshida K, Makishima H, Iwanaga M, Ma G, Nosaka K, Hishizawa M, Itonaga H, Imaizumi Y, Munakata W, Ogasawara H, Sato T, Sasai K, Muramoto K, Penova M, Kawaguchi T, Nakamura H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda T, Nakamaki T, Ishiyama K, Miyawaki S, Yoon SS, Tobinai K, Miyazaki Y, Takaori-Kondo A, Matsuda F, Takeuchi K, Nureki O, Aburatani H, Watanabe T, Shibata T, Matsuoka M, Miyano S, Shimoda K, Ogawa S.

    Integrated molecular analysis of adult T cell leukemia/lymphoma.

    Nat Genet. 2015 Nov;47(11):1304-15. doi: 10.1038/ng.3415. Epub 2015 Oct 5. PMID: 26437031.

    https://pubmed.ncbi.nlm.nih.gov/26437031/

CONTACT US

C

  • 患者様へ

    外来診療の方は外来予約センターより
    ご予約をお願いいたします。
    外来予約センター

  • 学生・研修医・医療関係者の方へ

    TEL
    096-373-5156
    FAX
    096-373-5158
    Mail
    nikyo@kumamoto-u.ac.jp
Copyright 2019 KUMAMOTO University HRI All Rights Reserved.