KUMAMOTO University

R

研究業績RESEARCH ACHIEVEMENTS

  1. 1.

    Nakamura T, Nakamura T, Amano M, Miyakawa T, Yamagata Y, Matsuoka M, Nakata H.
    A Conformational Escape Reaction of HIV-1 against an Allosteric Integrase Inhibitor.
    J Virol. 2020 Sep 15;94(19):e00486-20. doi: 10.1128/JVI.00486-20. PMID: 32611758; PMCID: PMC7495394

  2. 2.

    Ghosh AK, Kovela S, Osswald HL, Amano M, Aoki M, Agniswamy J, Wang YF, Weber IT, Mitsuya H.
    Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies.
    J Med Chem. 2020 May 14;63(9):4867-4879. doi: 10.1021/acs.jmedchem.0c00202. PMID: 32348139; PMCID: PMC7425579

  3. 3.

    Nishimura N, Radwan MO, Amano M, Endo S, Fujii E, Hayashi H, Ueno S, Ueno N, Tatetsu H, Hata H, Okamoto Y, Otsuka M, Mitsuya H, Matsuoka M, Okuno Y.

    Novel p97/VCP inhibitor induces endoplasmic reticulum stress and apoptosis in both bortezomib-sensitive and -resistant multiple myeloma cells.

    Cancer Sci. 2019 Oct;110(10):3275-3287. doi: 10.1111/cas.14154. Epub 2019 Aug 14. PMID: 31368616; PMCID: PMC6778635.

  4. 4.

    Onitsuka K, Tokuda R, Kuwata-Higashi N, Kumamoto H, Aoki M, Amano M, Kohgo S, Das D, Haraguchi K, Mitsuya H, Imoto S.

    Synthesis and evaluation of the anti-hepatitis B virus activity of 4′-Azido-thymidine analogs and 4′-Azido-2′-deoxy-5-methylcytidine analogs: structural insights for the development of a novel anti-HBV agent.

    Nucleosides Nucleotides Nucleic Acids. 2019 Sep 12;1-12. doi: 10.1080/15257770.2019.1664749. [Epub ahead of print]. PMID: 31514570.

  5. 5.

    Takamatsu Y, Aoki M, Bulut H, Das D, Amano M, Sheri VR, Kovari LC, Hayashi H, Delino NS, Ghosh AK, Mitsuya H.

    Novel Protease Inhibitors Containing C-5-Modified bis-Tetrahydrofuranylurethane and Aminobenzothiazole as P2 and P2′ Ligands That Exert Potent Antiviral Activity against Highly Multidrug-Resistant HIV-1 with a High Genetic Barrier against the Emergence of Drug Resistance.

    Antimicrob Agents Chemother. 2019 Jul 25;63(8):e00372-19. doi: 10.1128/AAC.00372-19. PMID: 31085520; PMCID: PMC6658756.

  6. 6.

    Amano M, Bulut H, Tamiya S, Nakamura T, Koh Y, Mitsuya H.

    Amino-acid inserts of HIV-1 capsid (CA) induce CA degradation and abrogate viral infectivity: Insights for the dynamics and mechanisms of HIV-1 CA decomposition.

    Sci Rep. 2019 Jul 8;9(1):9806. doi: 10.1038/s41598-019-46082-2. PMID: 31285456; PMCID: PMC6614453.

  7. 7.

    Amano M, Salcedo-Gómez PM, Yedidi RS, Zhao R, Hayashi H, Hasegawa K, Nakamura T, Martyr CD, Ghosh AK, Mitsuya H.

    Novel Central Nervous System (CNS)-Targeting Protease Inhibitors for Drug-Resistant HIV Infection and HIV-Associated CNS Complications.

    Antimicrob Agents Chemother. 2019 Jun 24;63(7):e00466-19. doi: 10.1128/AAC.00466-19. PMID: 31061155; PMCID: PMC6591644.

  8. 8.

    Nakata H, Maeda K, Das D, Chang SB, Matsuda K, Rao KV, Harada S, Yoshimura K, Ghosh AK, Mitsuya H.

    Activity and structural analysis of GRL-117C: a novel small molecule CCR5 inhibitor active against R5-tropic HIV-1s.

    Sci Rep. 2019 Mar 18;9(1):4828. doi: 10.1038/s41598-019-41080-w. PMID: 30886166; PMCID: PMC6423129.

  9. 9.

    Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T.

    Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report.

    J Clin Oncol. 2019 Mar 10;37(8):677-687. doi: 10.1200/JCO.18.00501. Epub 2019 Jan 18. PMID: 30657736; PMCID: PMC6494249.

  10. 10.

    Tagaya Y, Matsuoka M, Gallo R.

    40 years of the human T-cell leukemia virus: past, present, and future.

    F1000Res. 2019 Feb 28;8:F1000 Faculty Rev-228. doi: 10.12688/f1000research.17479.1. PMID: 30854194; PMCID: PMC6396841.

  11. 11.

    Inoue Y, Endo S, Matsuno N, Kikukawa Y, Shichijo T, Koga K, Takaki A, Iwanaga K, Nishimura N, Fuji S, Fukuda T, Nosaka K, Matsuoka M.

    Safety of mogamulizumab for relapsed ATL after allogeneic hematopoietic cell transplantation.

    Bone Marrow Transplant. 2019 Feb;54(2):338-342. doi: 10.1038/s41409-018-0291-5. Epub 2018 Aug 16. PMID: 30116017.

  12. 12.

    Ishida T, Jo T, Takemoto S, Suzushima H, Suehiro Y, Choi I, Yoshimitsu M, Saburi Y, Nosaka K, Utsunomiya A, Kobayashi Y, Yamamoto K, Fujiwara H, Ishitsuka K, Yoshida S, Taira N, Imada K, Kato K, Moriuchi Y, Yoshimura K, Takahashi T, Tobinai K, Ueda R.

    Follow-up of a randomised phase II study of chemotherapy alone or in combination with mogamulizumab in newly diagnosed aggressive adult T-cell leukaemia-lymphoma: impact on allogeneic haematopoietic stem cell transplantation.

    Br J Haematol. 2019 Feb;184(3):479-483. doi: 10.1111/bjh.15123. Epub 2018 Feb 7. PMID: 29411857.

  13. 13.

    Inoue Y, Endo S, Matsuno N, Kikukawa Y, Shichijo T, Koga K, Takaki A, Iwanaga K, Nishimura N, Fuji S, Fukuda T, Nosaka K, Matsuoka M.

    Safety of mogamulizumab for relapsed ATL after allogeneic hematopoietic cell transplantation.

    Bone Marrow Transplant. 2019 Feb;54(2):338-342. doi: 10.1038/s41409-018-0291-5. Epub 2018 Aug 16. PMID: 30116017.

  14. 14.

    Ito R, Inamoto Y, Inoue Y, Ito A, Tanaka T, Fuji S, Okinaka K, Kurosawa S, Kim SW, Yamashita T, Fukuda T.

    Characterization of Late Acute and Chronic Graft-Versus-Host Disease according to the 2014 National Institutes of Health Consensus Criteria in Japanese Patients.

    Biol Blood Marrow Transplant. 2019 Feb;25(2):293-300. doi: 10.1016/j.bbmt.2018.09.014. Epub 2018 Sep 19. PMID: 30244104.

  15. 15.

    Maeda M, Muraki Y, Kosaka T, Yamada T, Aoki Y, Kaku M, Kawaguchi T, Seki M, Tanabe Y, Fujita N, Morita K, Yanagihara K, Yoshida K, Niki Y.

    The first nationwide survey of antimicrobial stewardship programs conducted by the Japanese Society of Chemotherapy.

    J Infect Chemother. 2019 Feb;25(2):83-88. doi: 10.1016/j.jiac.2018.11.001. Epub 2018 Nov 22. PMID: 30473181.

  16. 16.

    Fuji S, Inoue Y, Utsunomiya A, Moriuchi Y, Choi I, Otsuka E, Henzan H, Kato K, Nakachi S, Yamamoto H, Fukuda T.

    Impact of pretransplant central nervous system invasion in patients with aggressive adult T-cell leukemia lymphoma.

    Bone Marrow Transplant. 2019 Jan;54(1):134-137. doi: 10.1038/s41409-018-0248-8. Epub 2018 Jun 13. PMID: 29899570.

  17. 17.

    Endo S, Nishimura N, Kawano Y, Ueno N, Ueno S, Tatetsu H, Komohara Y, Takeya M, Hata H, Mitsuya H, Masao M, Okuno Y.

    MUC1/KL-6 expression confers an aggressive phenotype upon myeloma cells.

    Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):246-252. doi: 10.1016/j.bbrc.2018.11.016. Epub 2018 Nov 10. PMID: 30420285.

  18. 18.

    Saburi M, Ogata M, Itani K, Kohno K, Soga Y, Kondo Y, Kawano Y, Nakayama T.

    Rare concurrent indolent B-cell lymphoma and plasmablastic transformation of myeloma.

    J Clin Exp Hematop. 2018 Dec 13;58(4):175-179. doi: 10.3960/jslrt.18019. Epub 2018 Oct 10. PMID: 30305474; PMCID: PMC6407474.

  19. 19.

    Yuki A, Shinkuma S, Hayashi R, Fujikawa H, Kato T, Homma E, Hamade Y, Onodera O, Matsuoka M, Shimizu H, Iwata H, Abe R.

    CADM1 is a diagnostic marker in early-stage mycosis fungoides: Multicenter study of 58 cases.

    J Am Acad Dermatol. 2018 Dec;79(6):1039-1046. doi: 10.1016/j.jaad.2018.06.025. Epub 2018 Jun 19. PMID: 29928911.

  20. 20.

    Kasamatsu T, Ozaki S, Saitoh T, Konishi J, Sunami K, Itagaki M, Asaoku H, Cho T, Handa H, Hagiwara S, Wakayama T, Negoro A, Takezako N, Harada N, Kuroda Y, Nakaseko C, Miyake T, Inoue N, Hata H, Shimazaki C, Ohno T, Kuroda J, Murayama T, Kobayashi T, Abe M, Ishida T, Nagura E, Shimizu K.

    Unsuppressed serum albumin levels may jeopardize the clinical relevance of the international staging system to patients with light chain myeloma.

    Hematol Oncol. 2018 Dec;36(5):792-800. doi: 10.1002/hon.2559. Epub 2018 Sep 19. PMID: 30176173.

  21. 21.

    Hosokawa K, Sugimori C, Ishiyama K, Takamatsu H, Noji H, Shichishima T, Obara N, Chiba S, Ninomiya H, Shirasugi Y, Nakamura Y, Ando K, Ueda Y, Yonemura Y, Kawaguchi T, Nishimura JI, Kanakura Y, Nakao S.

    Establishment of a flow cytometry assay for detecting paroxysmal nocturnal hemoglobinuria-type cells specific to patients with bone marrow failure.

    Ann Hematol. 2018 Dec;97(12):2289-2297. doi: 10.1007/s00277-018-3443-1. Epub 2018 Jul 24. PMID: 30039297.

  22. 22.

    Yasuma-Mitobe K, Matsuoka M.

    The Roles of Coinhibitory Receptors in Pathogenesis of Human Retroviral Infections.

    Front Immunol. 2018 Nov 27;9:2755. doi: 10.3389/fimmu.2018.02755. PMID: 30538707; PMCID: PMC6277675.

  23. 23.

    Song Z, Wu W, Chen M, Cheng W, Yu J, Fang J, Xu L, Yasunaga JI, Matsuoka M, Zhao T.

    Long Noncoding RNA ANRIL Supports Proliferation of Adult T-Cell Leukemia Cells through Cooperation with EZH2.

    J Virol. 2018 Nov 27;92(24):e00909-18. doi: 10.1128/JVI.00909-18. PMID: 30258009; PMCID: PMC6258931.

  24. 24.

    Yasuma-Mitobe K, Matsuoka M.

    The Roles of Coinhibitory Receptors in Pathogenesis of Human Retroviral Infections.

    Front Immunol. 2018 Nov 27;9:2755. doi: 10.3389/fimmu.2018.02755. PMID: 30538707; PMCID: PMC6277675.

  25. 25.

    Kumamoto H, Imoto S, Amano M, Kuwata-Higashi N, Baba M, Mitsuya H, Odanaka Y, Shimbara Matsubayashi S, Tanaka H, Haraguchi K.

    Synthesis, Anti-HBV, and Anti-HIV Activities of 3′-Halogenated Bis(hydroxymethyl)-cyclopentenyladenines.

    ACS Med Chem Lett. 2018 Nov 9;9(12):1211-1216. doi: 10.1021/acsmedchemlett.8b00374. PMID: 30613328; PMCID: PMC6295849.

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