KUMAMOTO University

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研究実績RESEARCH ACHIEVEMENTS

  1. 1 .

    Ueno N, Nishimura N, Ueno S, Endo S, Tatetsu H, Hirata S, Hata H, Matsuoka M, Mitsuya H, Okuno Y.

    PU.1 acts as tumor suppressor for myeloma cells through direct transcriptional repression of IRF4.

    Oncogene. 2017 Aug;36(31):4481-4497. doi: 10.1038/onc.2017.79. Epub 2017 Apr 3. PMID: 28368411.

  2. 2 .

    Nishimura N, Endo S, Ueno S, Ueno N, Tatetsu H, Hirata S, Hata H, Komohara Y, Takeya M, Mitsuya H, Okuno Y.

    A xenograft model reveals that PU.1 functions as a tumor suppressor for multiple myeloma in vivo.

    Biochem Biophys Res Commun. 2017 May 13;486(4):916-922. doi: 10.1016/j.bbrc.2017.03.124. Epub 2017 Mar 24. PMID: 28347818.

  3. 3 .

    Furuta R, Yasunaga JI, Miura M, Sugata K, Saito A, Akari H, Ueno T, Takenouchi N, Fujisawa JI, Koh KR, Higuchi Y, Mahgoub M, Shimizu M, Matsuda F, Melamed A, Bangham CR, Matsuoka M.

    Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo.

    PLoS Pathog. 2017 Nov 29;13(11):e1006722. doi: 10.1371/journal.ppat.1006722. PMID: 29186194; PMCID: PMC5724899.

  4. 4 .

    Kinosada H, Yasunaga JI, Shimura K, Miyazato P, Onishi C, Iyoda T, Inaba K, Matsuoka M.

    HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors.

    PLoS Pathog. 2017 Jan 3;13(1):e1006120. doi: 10.1371/journal.ppat.1006120. Erratum in: PLoS Pathog. 2017 Feb 23;13(2):e1006228. PMID: 28046066; PMCID: PMC5234849.

  5. 5 .

    Chao HW, Doi M, Fustin JM, Chen H, Murase K, Maeda Y, Hayashi H, Tanaka R, Sugawa M, Mizukuchi N, Yamaguchi Y, Yasunaga JI, Matsuoka M, Sakai M, Matsumoto M, Hamada S, Okamura H.

    Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway.

    Nat Commun. 2017 Dec 21;8(1):2238. doi: 10.1038/s41467-017-02207-7. PMID: 29269828; PMCID: PMC5740157.

  6. 6 .

    Takiuchi Y, Kobayashi M, Tada K, Iwai F, Sakurada M, Hirabayashi S, Nagata K, Shirakawa K, Shindo K, Yasunaga JI, Murakawa Y, Rajapakse V, Pommier Y, Matsuoka M, Takaori-Kondo A.

    HTLV-1 bZIP factor suppresses TDP1 expression through inhibition of NRF-1 in adult T-cell leukemia.

    Sci Rep. 2017 Oct 9;7(1):12849. doi: 10.1038/s41598-017-12924-0. PMID: 28993637; PMCID: PMC5634466.

  7. 7 .

    Bangham CRM, Matsuoka M.

    Human T-cell leukaemia virus type 1: parasitism and pathogenesis.

    Philos Trans R Soc Lond B Biol Sci. 2017 Oct 19;372(1732):20160272. doi: 10.1098/rstb.2016.0272. PMID: 28893939; PMCID: PMC5597739.

  8. 8 .

    Ghosh AK, Fyvie WS, Brindisi M, Steffey M, Agniswamy J, Wang YF, Aoki M, Amano M, Weber IT, Mitsuya H.

    Design, Synthesis, Biological Evaluation, and X-ray Studies of HIV-1 Protease Inhibitors with Modified P2′ Ligands of Darunavir.

    ChemMedChem. 2017 Dec 7;12(23):1942-1952. doi: 10.1002/cmdc.201700614. Epub 2017 Nov 24. PMID: 29110408; PMCID: PMC5896574.

  9. 9 .

    Ghosh AK, Sean Fyvie W, Brindisi M, Steffey M, Agniswamy J, Wang YF, Aoki M, Amano M, Weber IT, Mitsuya H.

    Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1′-P2′ ligands.

    Bioorg Med Chem Lett. 2017 Nov 1;27(21):4925-4931. doi: 10.1016/j.bmcl.2017.09.003. Epub 2017 Sep 6. PMID: 28958624; PMCID: PMC5647257.

  10. 10 .

    Amano M, Miguel Salcedo-Gómez P, Yedidi RS, Delino NS, Nakata H, Venkateswara Rao K, Ghosh AK, Mitsuya H.

    GRL-09510, a Unique P2-Crown-Tetrahydrofuranylurethane -Containing HIV-1 Protease Inhibitor, Maintains Its Favorable Antiviral Activity against Highly-Drug-Resistant HIV-1 Variants in vitro.

    Sci Rep. 2017 Sep 25;7(1):12235. doi: 10.1038/s41598-017-12052-9. PMID: 28947797; PMCID: PMC5613016.

  11. 11 .

    Kumamoto H, Fukano M, Imoto S, Kohgo S, Odanaka Y, Amano M, Kuwata-Higashi N, Mitsuya H, Haraguchi K, Fukuhara K.

    A novel entecavir analogue constructing with a spiro[2.4]heptane core structure in the aglycon moiety: Its synthesis and evaluation for anti-hepatitis B virus activity.

    Nucleosides Nucleotides Nucleic Acids. 2017 Jul 3;36(7):463-473. doi: 10.1080/15257770.2017.1322209. Epub 2017 Jun 2. PMID: 28574799.

  12. 12 .

    Ghosh AK, Brindisi M, Nyalapatla PR, Takayama J, Ella-Menye JR, Yashchuk S, Agniswamy J, Wang YF, Aoki M, Amano M, Weber IT, Mitsuya H.

    Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex.

    Bioorg Med Chem. 2017 Oct 1;25(19):5114-5127. doi: 10.1016/j.bmc.2017.04.005. Epub 2017 Apr 9. PMID: 28434781; PMCID: PMC5617771.

  13. 13 .

    Kawajiri A, Fuji S, Tanaka Y, Kono C, Hirakawa T, Tanaka T, Ito R, Inoue Y, Okinaka K, Kurosawa S, Inamoto Y, Kim SW, Yamashita T, Fukuda T.

    Clinical impact of hyperglycemia on days 0-7 after allogeneic stem cell transplantation.

    Bone Marrow Transplant. 2017 Aug;52(8):1156-1163. doi: 10.1038/bmt.2017.27. Epub 2017 Mar 20. PMID: 28319076.

  14. 14 .

    Tanaka Y, Kurosawa S, Tajima K, Tanaka T, Ito R, Inoue Y, Okinaka K, Inamoto Y, Fuji S, Kim SW, Tanosaki R, Yamashita T, Fukuda T.

    Increased incidence of oral and gastrointestinal secondary cancer after allogeneic hematopoietic stem cell transplantation.

    Bone Marrow Transplant. 2017 May;52(5):789-791. doi: 10.1038/bmt.2017.4. Epub 2017 Feb 13. PMID: 28194030.

  15. 15 .

    Kawano Y, Roccaro AM, Ghobrial IM, Azzi J.

    Multiple Myeloma and the Immune Microenvironment.

    Curr Cancer Drug Targets. 2017;17(9):806-818. doi: 10.2174/1568009617666170214102301. PMID: 28201978.

  16. 16 .

    Fuji S, Yamaguchi T, Inoue Y, Utsunomiya A, Moriuchi Y, Uchimaru K, Owatari S, Miyagi T, Taguchi J, Choi I, Otsuka E, Nakachi S, Yamamoto H, Kurosawa S, Tobinai K, Fukuda T.

    Development of a modified prognostic index for patients with aggressive adult T-cell leukemia-lymphoma aged 70 years or younger: possible risk-adapted management strategies including allogeneic transplantation.

    Haematologica. 2017 Jul;102(7):1258-1265. doi: 10.3324/haematol.2017.164996. Epub 2017 Mar 24. PMID: 28341734; PMCID: PMC5566038.

  17. 17 .

    Makita S, Munakata W, Watabe D, Maeshima AM, Taniguchi H, Toyoda K, Yamauchi N, Fukuhara S, Maruyama D, Kobayashi Y, Tobinai K.

    Azacitidine-induced acute lung injury in a patient with therapy-related myelodysplastic syndrome.

    J Int Med Res. 2017 Apr;45(2):886-893. doi: 10.1177/0300060517698331. Epub 2017 Mar 16. PMID: 28415946; PMCID: PMC5536648.

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