KUMAMOTO University

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研究実績RESEARCH ACHIEVEMENTS

  1. 1 .

    Yasuma K, Yasunaga J, Takemoto K, Sugata K, Mitobe Y, Takenouchi N, Nakagawa M, Suzuki Y, Matsuoka M.

    HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT).

    PLoS Pathog. 2016 Jan 6;12(1):e1005372. doi: 10.1371/journal.ppat.1005372. PMID: 26735971; PMCID: PMC4703212.

  2. 2 .

    Amano M, Salcedo-Gómez PM, Zhao R, Yedidi RS, Das D, Bulut H, Delino NS, Sheri VR, Ghosh AK, Mitsuya H.

    A Modified P1 Moiety Enhances In Vitro Antiviral Activity against Various Multidrug-Resistant HIV-1 Variants and In Vitro Central Nervous System Penetration Properties of a Novel Nonpeptidic Protease Inhibitor, GRL-10413.

    Antimicrob Agents Chemother. 2016 Nov 21;60(12):7046-7059. doi: 10.1128/AAC.01428-16. PMID: 27620483; PMCID: PMC5118983.

  3. 3 .

    Fuji S, Inoue Y, Utsunomiya A, Moriuchi Y, Uchimaru K, Choi I, Otsuka E, Henzan H, Kato K, Tomoyose T, Yamamoto H, Kurosawa S, Matsuoka K, Yamaguchi T, Fukuda T.

    Pretransplantation Anti-CCR4 Antibody Mogamulizumab Against Adult T-Cell Leukemia/Lymphoma Is Associated With Significantly Increased Risks of Severe and Corticosteroid-Refractory Graft-Versus-Host Disease, Nonrelapse Mortality, and Overall Mortality.

    J Clin Oncol. 2016 Oct 1;34(28):3426-33. doi: 10.1200/JCO.2016.67.8250. Epub 2016 Aug 9. PMID: 27507878.

  4. 4 .

    Salie ZL, Kirby KA, Michailidis E, Marchand B, Singh K, Rohan LC, Kodama EN, Mitsuya H, Parniak MA, Sarafianos SG.

    Structural basis of HIV inhibition by translocation-defective RT inhibitor 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA).

    Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9274-9. doi: 10.1073/pnas.1605223113. Epub 2016 Aug 3. PMID: 27489345; PMCID: PMC4995989.

  5. 5 .

    Makita S, Fuji S, Takano K, Tanaka T, Inoue Y, Ito R, Ito A, Hayashi Y, Tajima K, Okinaka K, Kurosawa S, Kim SW, Yamashita T, Tanosaki R, Tobinai K, Fukuda T.

    Clinical Outcomes after Allogeneic Stem Cell Transplantation for Adult Lymphoblastic Lymphoma.

    J Clin Exp Hematop. 2016;56(1):28-33. doi: 10.3960/jslrt.56.28. PMID: 27334855; PMCID: PMC6144282.

  6. 6 .

    Nakamura T, Campbell JR, Moore AR, Otsu S, Aikawa H, Tamamura H, Mitsuya H.

    Development and validation of a cell-based assay system to assess human immunodeficiency virus type 1 integrase multimerization.

    J Virol Methods. 2016 Oct;236:196-206. doi: 10.1016/j.jviromet.2016.07.023. Epub 2016 Jul 26. PMID: 27474494.

  7. 7 .

    Kuriyama K, Fuji S, Inamoto Y, Tajima K, Tanaka T, Inoue Y, Ito R, Hayashi Y, Ito A, Kurosawa S, Kim SW, Yamashita T, Fukuda T.

    Impact of low-dose rabbit anti-thymocyte globulin in unrelated hematopoietic stem cell transplantation.

    Int J Hematol. 2016 Apr;103(4):453-60. doi: 10.1007/s12185-016-1947-9. Epub 2016 Feb 9. PMID: 26857285.

  8. 8 .

    Endo S, Amano M, Nishimura N, Ueno N, Ueno S, Yuki H, Fujiwara S, Wada N, Hirata S, Hata H, Mitsuya H, Okuno Y.

    Immunomodulatory drugs act as inhibitors of DNA methyltransferases and induce PU.1 up-regulation in myeloma cells.

    Biochem Biophys Res Commun. 2016 Jan 8;469(2):236-42. doi: 10.1016/j.bbrc.2015.11.116. Epub 2015 Nov 30. PMID: 26657848.

  9. 9 .

    Fuji S, Fujiwara H, Nakano N, Wake A, Inoue Y, Fukuda T, Hidaka M, Moriuchi Y, Miyamoto T, Uike N, Taguchi J, Eto T, Tomoyose T, Kondo T, Yamanoha A, Ichinohe T, Atsuta Y, Utsunomiya A; ATL Working Group of the Japan Society for Hematopoietic Cell Transplantation.

    Early application of related SCT might improve clinical outcome in adult T-cell leukemia/lymphoma.

    Bone Marrow Transplant. 2016 Feb;51(2):205-11. doi: 10.1038/bmt.2015.265. Epub 2015 Nov 2. PMID: 26524263.

  10. 10 .

    Kumamoto H, Fukano M, Nakano T, Iwagami K, Takeyama C, Kohgo S, Imoto S, Amano M, Kuwata-Higashi N, Aoki M, Abe H, Mitsuya H, Fukuhara K, Haraguchi K.

    Diastereoselective Synthesis of 6″-(Z)- and 6″-(E)-Fluoro Analogues of Anti-hepatitis B Virus Agent Entecavir and Its Evaluation of the Activity and Toxicity Profile of the Diastereomers.

    J Org Chem. 2016 Apr 1;81(7):2827-36. doi: 10.1021/acs.joc.6b00105. Epub 2016 Mar 24. PMID: 27009432.

  11. 11 .

    Tanaka Y, Kurosawa S, Tajima K, Tanaka T, Ito R, Inoue Y, Okinaka K, Inamoto Y, Fuji S, Kim SW, Tanosaki R, Yamashita T, Fukuda T.

    Analysis of non-relapse mortality and causes of death over 15 years following allogeneic hematopoietic stem cell transplantation.

    Bone Marrow Transplant. 2016 Apr;51(4):553-9. doi: 10.1038/bmt.2015.330. Epub 2016 Jan 11. PMID: 26752142.

  12. 12 .

    Ghosh AK, Osswald HL, Glauninger K, Agniswamy J, Wang YF, Hayashi H, Aoki M, Weber IT, Mitsuya H. Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV-1 Protease Inhibitors: Design, Synthesis, Protein X-ray Structural Studies, and Biological Evaluation. J Med Chem. 2016 Jul 28;59(14):6826-37. doi: 10.1021/acs.jmedchem.6b00639. Epub 2016 Jul 7. PMID: 27389367; PMCID: PMC5360270.

  13. 13 .

    Inoue Y, Fuji S, Tanosaki R, Fukuda T.

    Pretransplant mogamulizumab against ATLL might increase the risk of acute GVHD and non-relapse mortality.

    Bone Marrow Transplant. 2016 May;51(5):725-7. doi: 10.1038/bmt.2015.315. Epub 2015 Dec 21. PMID: 26691420.

  14. 14 .

    Higuchi Y, Tokunaga K, Watanabe Y, Kawakita T, Harada N, Yamaguchi S, Nosaka K, Mitsuya H, Asou N.

    Lineage switch with t(6;11)(q27;q23) from T-cell lymphoblastic lymphoma to acute monoblastic leukemia at relapse.

    Cancer Genet. 2016 Jun;209(6):267-71. doi: 10.1016/j.cancergen.2016.05.070. Epub 2016 May 18. PMID: 27268298.

  15. 15 .

    Moschetta M, Kawano Y, Podar K.

    Targeting the Bone Marrow Microenvironment.

    Cancer Treat Res. 2016;169:63-102. doi: 10.1007/978-3-319-40320-5_6. PMID: 27696259.

  16. 16 .

    Fujiwara S, Mochinaga H, Nakata H, Ohshima K, Matsumoto M, Uchiba M, Mikami Y, Hata H, Okuno Y, Mitsuya H, Nosaka K.

    Successful treatment of TAFRO syndrome, a variant type of multicentric Castleman disease with thrombotic microangiopathy, with anti-IL-6 receptor antibody and steroids.

    Int J Hematol. 2016 Jun;103(6):718-23. doi: 10.1007/s12185-016-1978-2. Epub 2016 Mar 15. PMID: 26980221.

  17. 17 .

    Glavey SV, Manier S, Sacco A, Salem K, Kawano Y, Bouyssou J, Ghobrial IM, Roccaro AM.

    Epigenetics in Multiple Myeloma.

    Cancer Treat Res. 2016;169:35-49. doi: 10.1007/978-3-319-40320-5_4. PMID: 27696257.

  18. 18 .

    Kikukawa Y, Hata H, Ueda M, Yamashita T, Nasu S, Ide K, Ueno S, Ando Y, Mitsuya H, Okuno Y.

    Successful Treatment of Amyloid Light-chain Amyloidosis in a Charcot-Marie-Tooth Disease Patient with Lenalidomide, Cyclophosphamide, and Dexamethasone.

    Intern Med. 2016;55(18):2707-12. doi: 10.2169/internalmedicine.55.5815. Epub 2016 Sep 15. PMID: 27629972.

  19. 19 .

    Manier S, Kawano Y, Bianchi G, Roccaro AM, Ghobrial IM.

    Cell autonomous and microenvironmental regulation of tumor progression in precursor states of multiple myeloma.

    Curr Opin Hematol. 2016 Jul;23(4):426-33. doi: 10.1097/MOH.0000000000000259. PMID: 27101529.

  20. 20 .

    Alam M, Kuwata T, Shimura K, Yokoyama M, Ramirez Valdez KP, Tanaka K, Maruta Y, Oishi S, Fujii N, Sato H, Matsuoka M, Matsushita S.

    Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors.

    Retrovirology. 2016 Sep 27;13(1):70. doi: 10.1186/s12977-016-0304-7. PMID: 27670680; PMCID: PMC5037607.

  21. 21 .

    Roccaro AM, Sacco A, Shi J, Chiarini M, Perilla-Glen A, Manier S, Glavey S, Aljawai Y, Mishima Y, Kawano Y, Moschetta M, Correll M, Improgo MR, Brown JR, Imberti L, Rossi G, Castillo JJ, Treon SP, Freedman ML, Van Allen EM, Hide W, Hiller E, Rainville I, Ghobrial IM.

    Exome sequencing reveals recurrent germ line variants in patients with familial Waldenström macroglobulinemia.

    Blood. 2016 May 26;127(21):2598-606. doi: 10.1182/blood-2015-11-680199. Epub 2016 Feb 22. PMID: 26903547.

  22. 22 .

    Sugata K, Yasunaga J, Miura M, Akari H, Utsunomiya A, Nosaka K, Watanabe Y, Suzushima H, Koh KR, Nakagawa M, Kohara M, Matsuoka M.

    Enhancement of anti-STLV-1/HTLV-1 immune responses through multimodal effects of anti-CCR4 antibody.

    Sci Rep. 2016 Jun 2;6:27150. doi: 10.1038/srep27150. PMID: 27250643; PMCID: PMC4890010.

  23. 23 .

    Moschetta M, Mishima Y, Kawano Y, Manier S, Paiva B, Palomera L, Aljawai Y, Calcinotto A, Unitt C, Sahin I, Sacco A, Glavey S, Shi J, Reagan MR, Prosper F, Bellone M, Chesi M, Bergsagel LP, Vacca A, Roccaro AM, Ghobrial IM.

    Targeting vasculogenesis to prevent progression in multiple myeloma.

    Leukemia. 2016 May;30(5):1103-15. doi: 10.1038/leu.2016.3. Epub 2016 Feb 3. PMID: 26859080.

  24. 24 .

    Kuribayashi W, Takizawa K, Sugata K, Kuramitsu M, Momose H, Sasaki E, Hiradate Y, Furuhata K, Asada Y, Iwama A, Matsuoka M, Mizukami T, Hamaguchi I.

    Impact of the SCF signaling pathway on leukemia stem cell-mediated ATL initiation and progression in an HBZ transgenic mouse model.

    Oncotarget. 2016 Aug 9;7(32):51027-51043. doi: 10.18632/oncotarget.10210. PMID: 27340921; PMCID: PMC5239456.

  25. 25 .

    Maeshima AM, Taniguchi H, Toyoda K, Yamauchi N, Makita S, Fukuhara S, Munakata W, Maruyama D, Kobayashi Y, Tobinai K.

    Clinicopathological features of histological transformation from extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue to diffuse large B-cell lymphoma: an analysis of 467 patients.

    Br J Haematol. 2016 Sep;174(6):923-31. doi: 10.1111/bjh.14153. Epub 2016 Jul 27. PMID: 27460179.

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