KUMAMOTO University

R

研究業績RESEARCH ACHIEVEMENTS

  1. 51.

    Tokuhira M, Kimura Y, Sugimoto K, Nakazato T, Ishikawa M, Fujioka I, Takaku T, Iriyama N, Sato E, Fujita H, Hatta Y, Komatsu N, Asou N, Kizaki M, Kawaguchi T.

    Efficacy and safety of nilotinib therapy in patients with newly diagnosed chronic myeloid leukemia in the chronic phase.

    Med Oncol. 2018 Feb 13;35(3):38. doi: 10.1007/s12032-018-1093-8. PMID: 29442179.

  2. 52.

    Sato T, Coler-Reilly ALG, Yagishita N, Araya N, Inoue E, Furuta R, Watanabe T, Uchimaru K, Matsuoka M, Matsumoto N, Hasegawa Y, Yamano Y.

    Mogamulizumab (Anti-CCR4) in HTLV-1-Associated Myelopathy.

    N Engl J Med. 2018 Feb 8;378(6):529-538. doi: 10.1056/NEJMoa1704827. PMID: 29414279.

  3. 53.

    Mahgoub M, Yasunaga JI, Iwami S, Nakaoka S, Koizumi Y, Shimura K, Matsuoka M.

    Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells.

    Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1269-E1278. doi: 10.1073/pnas.1715724115. Epub 2018 Jan 22. PMID: 29358408; PMCID: PMC5819419.

  4. 54.

    Kawashima I, Inamoto Y, Maeshima AM, Nomoto J, Tajima K, Honda T, Shichijo T, Kawajiri A, Takemura T, Onishi A, Ito A, Tanaka T, Fuji S, Kurosawa S, Kim SW, Maruyama D, Tobinai K, Kobayashi Y, Fukuda T.

    Double-Expressor Lymphoma Is Associated with Poor Outcomes after Allogeneic Hematopoietic Cell Transplantation.

    Biol Blood Marrow Transplant. 2018 Feb;24(2):294-300. doi: 10.1016/j.bbmt.2017.10.013. Epub 2017 Oct 14. PMID: 29037890.

  5. 55.

    Shimazaki C, Hata H, Iida S, Ueda M, Katoh N, Sekijima Y, Ikeda S, Yazaki M, Fukushima W, Ando Y.

    Nationwide Survey of 741 Patients with Systemic Amyloid Light-chain Amyloidosis in Japan.

    Intern Med. 2018 Jan 15;57(2):181-187. doi: 10.2169/internalmedicine.9206-17. Epub 2017 Nov 1. PMID: 29093404; PMCID: PMC5820034.

  6. 56.

    Kataoka K, Iwanaga M, Yasunaga JI, Nagata Y, Kitanaka A, Kameda T, Yoshimitsu M, Shiraishi Y, Sato-Otsubo A, Sanada M, Chiba K, Tanaka H, Ochi Y, Aoki K, Suzuki H, Shiozawa Y, Yoshizato T, Sato Y, Yoshida K, Nosaka K, Hishizawa M, Itonaga H, Imaizumi Y, Munakata W, Shide K, Kubuki Y, Hidaka T, Nakamaki T, Ishiyama K, Miyawaki S, Ishii R, Nureki O, Tobinai K, Miyazaki Y, Takaori-Kondo A, Shibata T, Miyano S, Ishitsuka K, Utsunomiya A, Shimoda K, Matsuoka M, Watanabe T, Ogawa S.

    Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma.

    Blood. 2018 Jan 11;131(2):215-225. doi: 10.1182/blood-2017-01-761874. Epub 2017 Oct 30. PMID: 29084771; PMCID: PMC5757690.

  7. 57.

    Yasunaga JI, Matsuoka M.

    Oncogenic spiral by infectious pathogens: Cooperation of multiple factors in cancer development.

    Cancer Sci. 2018 Jan;109(1):24-32. doi: 10.1111/cas.13443. Epub 2017 Dec 3. PMID: 29143406; PMCID: PMC5765297.

  8. 58.

    Yasunaga JI, Matsuoka M.

    Oncogenic spiral by infectious pathogens: Cooperation of multiple factors in cancer development.

    Cancer Sci. 2018 Jan;109(1):24-32. doi: 10.1111/cas.13443. Epub 2017 Dec 3. PMID: 29143406; PMCID: PMC5765297.

  9. 59.

    Komohara Y, Noyori O, Saito Y, Takeya H, Baghdadi M, Kitagawa F, Hama N, Ishikawa K, Okuno Y, Nosaka K, Seino KI, Matsuoka M, Suzu S.

    Potential anti-lymphoma effect of M-CSFR inhibitor in adult T-cell leukemia/lymphoma.

    J Clin Exp Hematop. 2018;58(4):152-160. doi: 10.3960/jslrt.18034. PMID: 30541986; PMCID: PMC6407477.

  10. 60.

    Shichijo T, Fuji S.

    Hematopoietic stem cell transplantation for T-cell lymphoma.

    Adv Cell Gene Ther. 2018;1:e6. doi.org/10.1002/acg2.6.

  11. 61.

    Satoru Kohgo, Shuhei Imoto, Ryoh Tokuda, Yuki Takamatsu, Nobuyo Higashi-Kuwata, Manabu Aoki, Masayuki Amano, Hisao Kansui, Kengo Onitsuka, Kenji Maeda, Hiroaki Mitsuya.

    Synthesis of 4’‐Substituted Purine 2’‐Deoxynucleosides and Their Activity against Human Immunodeficiency Virus Type 1 and Hepatitis B Virus.

    ChemistrySelect. 2018;3(11):3313–3317. doi.org/10.1002/slct.201800527

  12. 62.

    Kawaguchi T.

    [Management of paroxysmal nocturnal hemoglobinuria: an update].

    Rinsho Ketsueki. 2018;59(6):703-710. Japanese. doi: 10.11406/rinketsu.59.703. PMID: 29973448.

  13. 63.

    Chao HW, Doi M, Fustin JM, Chen H, Murase K, Maeda Y, Hayashi H, Tanaka R, Sugawa M, Mizukuchi N, Yamaguchi Y, Yasunaga JI, Matsuoka M, Sakai M, Matsumoto M, Hamada S, Okamura H.

    Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway.

    Nat Commun. 2017 Dec 21;8(1):2238. doi: 10.1038/s41467-017-02207-7. PMID: 29269828; PMCID: PMC5740157.

  14. 64.

    Ghosh AK, Fyvie WS, Brindisi M, Steffey M, Agniswamy J, Wang YF, Aoki M, Amano M, Weber IT, Mitsuya H.

    Design, Synthesis, Biological Evaluation, and X-ray Studies of HIV-1 Protease Inhibitors with Modified P2′ Ligands of Darunavir.

    ChemMedChem. 2017 Dec 7;12(23):1942-1952. doi: 10.1002/cmdc.201700614. Epub 2017 Nov 24. PMID: 29110408; PMCID: PMC5896574.

  15. 65.

    Furuta R, Yasunaga JI, Miura M, Sugata K, Saito A, Akari H, Ueno T, Takenouchi N, Fujisawa JI, Koh KR, Higuchi Y, Mahgoub M, Shimizu M, Matsuda F, Melamed A, Bangham CR, Matsuoka M.

    Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo.

    PLoS Pathog. 2017 Nov 29;13(11):e1006722. doi: 10.1371/journal.ppat.1006722. PMID: 29186194; PMCID: PMC5724899.

  16. 66.

    Ghosh AK, Sean Fyvie W, Brindisi M, Steffey M, Agniswamy J, Wang YF, Aoki M, Amano M, Weber IT, Mitsuya H.

    Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1′-P2′ ligands.

    Bioorg Med Chem Lett. 2017 Nov 1;27(21):4925-4931. doi: 10.1016/j.bmcl.2017.09.003. Epub 2017 Sep 6. PMID: 28958624; PMCID: PMC5647257.

  17. 67.

    Bangham CRM, Matsuoka M.

    Human T-cell leukaemia virus type 1: parasitism and pathogenesis.

    Philos Trans R Soc Lond B Biol Sci. 2017 Oct 19;372(1732):20160272. doi: 10.1098/rstb.2016.0272. PMID: 28893939; PMCID: PMC5597739.

  18. 68.

    Takiuchi Y, Kobayashi M, Tada K, Iwai F, Sakurada M, Hirabayashi S, Nagata K, Shirakawa K, Shindo K, Yasunaga JI, Murakawa Y, Rajapakse V, Pommier Y, Matsuoka M, Takaori-Kondo A.

    HTLV-1 bZIP factor suppresses TDP1 expression through inhibition of NRF-1 in adult T-cell leukemia.

    Sci Rep. 2017 Oct 9;7(1):12849. doi: 10.1038/s41598-017-12924-0. PMID: 28993637; PMCID: PMC5634466.

  19. 69.

    Ghosh AK, Brindisi M, Nyalapatla PR, Takayama J, Ella-Menye JR, Yashchuk S, Agniswamy J, Wang YF, Aoki M, Amano M, Weber IT, Mitsuya H.

    Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex.

    Bioorg Med Chem. 2017 Oct 1;25(19):5114-5127. doi: 10.1016/j.bmc.2017.04.005. Epub 2017 Apr 9. PMID: 28434781; PMCID: PMC5617771.

  20. 70.

    Amano M, Miguel Salcedo-Gómez P, Yedidi RS, Delino NS, Nakata H, Venkateswara Rao K, Ghosh AK, Mitsuya H.

    GRL-09510, a Unique P2-Crown-Tetrahydrofuranylurethane -Containing HIV-1 Protease Inhibitor, Maintains Its Favorable Antiviral Activity against Highly-Drug-Resistant HIV-1 Variants in vitro.

    Sci Rep. 2017 Sep 25;7(1):12235. doi: 10.1038/s41598-017-12052-9. PMID: 28947797; PMCID: PMC5613016.

  21. 71.

    Kawajiri A, Fuji S, Tanaka Y, Kono C, Hirakawa T, Tanaka T, Ito R, Inoue Y, Okinaka K, Kurosawa S, Inamoto Y, Kim SW, Yamashita T, Fukuda T.

    Clinical impact of hyperglycemia on days 0-7 after allogeneic stem cell transplantation.

    Bone Marrow Transplant. 2017 Aug;52(8):1156-1163. doi: 10.1038/bmt.2017.27. Epub 2017 Mar 20. PMID: 28319076.

  22. 72.

    Ueno N, Nishimura N, Ueno S, Endo S, Tatetsu H, Hirata S, Hata H, Matsuoka M, Mitsuya H, Okuno Y.

    PU.1 acts as tumor suppressor for myeloma cells through direct transcriptional repression of IRF4.

    Oncogene. 2017 Aug;36(31):4481-4497. doi: 10.1038/onc.2017.79. Epub 2017 Apr 3. PMID: 28368411.

  23. 73.

    Kumamoto H, Fukano M, Imoto S, Kohgo S, Odanaka Y, Amano M, Kuwata-Higashi N, Mitsuya H, Haraguchi K, Fukuhara K.

    A novel entecavir analogue constructing with a spiro[2.4]heptane core structure in the aglycon moiety: Its synthesis and evaluation for anti-hepatitis B virus activity.

    Nucleosides Nucleotides Nucleic Acids. 2017 Jul 3;36(7):463-473. doi: 10.1080/15257770.2017.1322209. Epub 2017 Jun 2. PMID: 28574799.

  24. 74.

    Fuji S, Yamaguchi T, Inoue Y, Utsunomiya A, Moriuchi Y, Uchimaru K, Owatari S, Miyagi T, Taguchi J, Choi I, Otsuka E, Nakachi S, Yamamoto H, Kurosawa S, Tobinai K, Fukuda T.

    Development of a modified prognostic index for patients with aggressive adult T-cell leukemia-lymphoma aged 70 years or younger: possible risk-adapted management strategies including allogeneic transplantation.

    Haematologica. 2017 Jul;102(7):1258-1265. doi: 10.3324/haematol.2017.164996. Epub 2017 Mar 24. PMID: 28341734; PMCID: PMC5566038.

  25. 75.

    Nishimura N, Endo S, Ueno S, Ueno N, Tatetsu H, Hirata S, Hata H, Komohara Y, Takeya M, Mitsuya H, Okuno Y.

    A xenograft model reveals that PU.1 functions as a tumor suppressor for multiple myeloma in vivo.

    Biochem Biophys Res Commun. 2017 May 13;486(4):916-922. doi: 10.1016/j.bbrc.2017.03.124. Epub 2017 Mar 24. PMID: 28347818.

CONTACT US

C

  • 患者様へ

    外来診療の方は外来予約センターより
    ご予約をお願いいたします。
    外来予約センター

  • 学生・研修医・医療関係者の方へ

    TEL
    096-373-5156
    FAX
    096-373-5158
    Mail
    nikyo@kumamoto-u.ac.jp
Copyright 2019 KUMAMOTO University HRI All Rights Reserved.