Ghosh AK, Schiltz GE, Rusere LN, Osswald HL, Walters DE, Amano M, Mitsuya H.

Design and synthesis of potent macrocyclic HIV-1 protease inhibitors involving P1-P2 ligands.

Org Biomol Chem. 2014 Sep 21;12(35):6842-54. doi: 10.1039/c4ob00738g. PMID: 25050776; PMCID: PMC4133278.

https://pubmed.ncbi.nlm.nih.gov/25050776/

Michailidis E, Huber AD, Ryan EM, Ong YT, Leslie MD, Matzek KB, Singh K, Marchand B, Hagedorn AN, Kirby KA, Rohan LC, Kodama EN, Mitsuya H, Parniak MA, Sarafianos SG.

4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) inhibits HIV-1 reverse transcriptase with multiple mechanisms.

J Biol Chem. 2014 Aug 29;289(35):24533-48. doi: 10.1074/jbc.M114.562694. Epub 2014 Jun 26. PMID: 24970894; PMCID: PMC4148878.

https://pubmed.ncbi.nlm.nih.gov/24970894/

Hayashi H, Takamune N, Nirasawa T, Aoki M, Morishita Y, Das D, Koh Y, Ghosh AK, Misumi S, Mitsuya H.

Dimerization of HIV-1 protease occurs through two steps relating to the mechanism of protease dimerization inhibition by darunavir.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12234-9. doi: 10.1073/pnas.1400027111. Epub 2014 Aug 4. PMID: 25092296; PMCID: PMC4142999.

https://pubmed.ncbi.nlm.nih.gov/25092296/

Zhang W, Parniak MA, Mitsuya H, Sarafianos SG, Graebing PW, Rohan LC.

Preformulation studies of EFdA, a novel nucleoside reverse transcriptase inhibitor for HIV prevention.

Drug Dev Ind Pharm. 2014 Aug;40(8):1101-11. doi: 10.3109/03639045.2013.809535. Epub 2013 Jul 10. PMID: 23841536; PMCID: PMC4136418.

https://pubmed.ncbi.nlm.nih.gov/23841536/

Maie K, Fuji S, Tajima K, Tatsuno M, Yamagata S, Takahashi N, Ueda R, Hashimoto H, Takano K, Inoue Y, Ito A, Hayashi Y, Okinaka K, Kurosawa S, Kim SW, Tanosaki R, Heike Y, Yamashita T, Fukuda T.

A higher number of infused CD34(+) cells has a positive impact on the clinical outcome after related PBSC transplantation.

Bone Marrow Transplant. 2014 Aug;49(8):1113-5. doi: 10.1038/bmt.2014.94. Epub 2014 May 5. PMID: 24797181.

Zhao T, Satou Y, Matsuoka M.

Development of T cell lymphoma in HTLV-1 bZIP factor and Tax double transgenic mice.

Arch Virol. 2014 Jul;159(7):1849-56. doi: 10.1007/s00705-014-2099-y. Epub 2014 May 13. PMID: 24818712.

https://pubmed.ncbi.nlm.nih.gov/24818712/

Yedidi RS, Garimella H, Aoki M, Aoki-Ogata H, Desai DV, Chang SB, Davis DA, Fyvie WS, Kaufman JD, Smith DW, Das D, Wingfield PT, Maeda K, Ghosh AK, Mitsuya H.

A conserved hydrogen-bonding network of P2 bis-tetrahydrofuran-containing HIV-1 protease inhibitors (PIs) with a protease active-site amino acid backbone aids in their activity against PI-resistant HIV.

Antimicrob Agents Chemother. 2014 Jul;58(7):3679-88. doi: 10.1128/AAC.00107-14. Epub 2014 Apr 21. PMID: 24752271; PMCID: PMC4068604.

https://pubmed.ncbi.nlm.nih.gov/24752271/

Toyoda K, Abe Y, Tsuda M, Haji S, Choi I, Suehiro Y, Kiyasu J, Ohshima K, Uike N.

[Successful treatment with oral low-dose sobuzoxane and etoposide combined with rituximab in an elderly patient with HHV-8-negative primary effusion lymphoma-like lymphoma].

Rinsho Ketsueki. 2014 Jul;55(7):815-9. Japanese. PMID: 25098519.

https://pubmed.ncbi.nlm.nih.gov/25098519/

Takamatsu A, Abe Y, Suehiro Y, Choi I, Toyoda K, Shiratsuchi M, Uike N.

Successful treatment with allogeneic hematopoietic stem cell transplant in a mature B-cell leukemia with MYC and BCL2 translocation.

Leuk Lymphoma. 2014 Jul;55(7):1663-4. doi: 10.3109/10428194.2013.844342. Epub 2013 Nov 6. PMID: 24033111.

https://pubmed.ncbi.nlm.nih.gov/24033111/

Cook LB, Melamed A, Niederer H, Valganon M, Laydon D, Foroni L, Taylor GP, Matsuoka M, Bangham CR.

The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma.

Blood. 2014 Jun 19;123(25):3925-31. doi: 10.1182/blood-2014-02-553602. Epub 2014 Apr 15. PMID: 24735963; PMCID: PMC4064332.

https://pubmed.ncbi.nlm.nih.gov/24735963/

Azuma Y, Kükenshöner T, Ma G, Yasunaga J, Imanishi M, Tanaka G, Nakase I, Maruno T, Kobayashi Y, Arndt KM, Matsuoka M, Futaki S.

Controlling leucine-zipper partner recognition in cells through modification of a-g interactions.

Chem Commun (Camb). 2014 Jun 18;50(48):6364-7. doi: 10.1039/c4cc00555d. PMID: 24803110.

https://pubmed.ncbi.nlm.nih.gov/24803110/

Yamaguchi S, Iwanaga E, Tokunaga K, Nanri T, Shimomura T, Suzushima H, Mitsuya H, Asou N.

IDH1 and IDH2 mutations confer an adverse effect in patients with acute myeloid leukemia lacking the NPM1 mutation.

Eur J Haematol. 2014 Jun;92(6):471-7. doi: 10.1111/ejh.12271. Epub 2014 Mar 3. PMID: 24443894.

https://pubmed.ncbi.nlm.nih.gov/24443894/

Muftuoglu Y, Sohl CD, Mislak AC, Mitsuya H, Sarafianos SG, Anderson KS.

Probing the molecular mechanism of action of the HIV-1 reverse transcriptase inhibitor 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) using pre-steady-state kinetics.

Antiviral Res. 2014 Jun;106:1-4. doi: 10.1016/j.antiviral.2014.03.001. Epub 2014 Mar 12. PMID: 24632447; PMCID: PMC4020981.

https://pubmed.ncbi.nlm.nih.gov/24632447/

Matsuzawa T, Kawamura T, Ogawa Y, Maeda K, Nakata H, Moriishi K, Koyanagi Y, Gatanaga H, Shimada S, Mitsuya H.

EFdA, a reverse transcriptase inhibitor, potently blocks HIV-1 ex vivo infection of Langerhans cells within epithelium.

J Invest Dermatol. 2014 Apr;134(4):1158-1161. doi: 10.1038/jid.2013.467. Epub 2013 Nov 11. PMID: 24384694.

https://pubmed.ncbi.nlm.nih.gov/24384694/

Hiramoto N, Kurosawa S, Tajima K, Okinaka K, Tada K, Kobayashi Y, Shinohara A, Inoue Y, Ueda R, Tanaka T, Kim SW, Yamashita T, Heike Y, Fukuda T.

Positive impact of chronic graft-versus-host disease on the outcome of patients with de novo myelodysplastic syndrome after allogeneic hematopoietic cell transplantation: a single-center analysis of 115 patients.

Eur J Haematol. 2014 Feb;92(2):137-46. doi: 10.1111/ejh.12214. Epub 2013 Nov 9. PMID: 24127668.

https://pubmed.ncbi.nlm.nih.gov/24127668/

Tanaka-Nakanishi A, Yasunaga J, Takai K, Matsuoka M.

HTLV-1 bZIP factor suppresses apoptosis by attenuating the function of FoxO3a and altering its localization.

Cancer Res. 2014 Jan 1;74(1):188-200. doi: 10.1158/0008-5472.CAN-13-0436. Epub 2013 Oct 31. PMID: 24177179.

https://pubmed.ncbi.nlm.nih.gov/24177179/

Maeda K, Desai DV, Aoki M, Nakata H, Kodama EN, Mitsuya H.

Delayed emergence of HIV-1 variants resistant to 4′-ethynyl-2-fluoro-2′-deoxyadenosine: comparative sequential passage study with lamivudine, tenofovir, emtricitabine and BMS-986001.

Antivir Ther. 2014;19(2):179-89. doi: 10.3851/IMP2697. Epub 2013 Oct 25. PMID: 24162098.

https://pubmed.ncbi.nlm.nih.gov/24162098/

Zhao T, Coutts A, Xu L, Yu J, Ohshima K, Matsuoka M.

HTLV-1 bZIP factor supports proliferation of adult T cell leukemia cells through suppression of C/EBPα signaling.

Retrovirology. 2013 Dec 21;10:159. doi: 10.1186/1742-4690-10-159. PMID: 24359396; PMCID: PMC3880043.

https://pubmed.ncbi.nlm.nih.gov/24359396/

Sato K, Misawa N, Iwami S, Satou Y, Matsuoka M, Ishizaka Y, Ito M, Aihara K, An DS, Koyanagi Y.

HIV-1 Vpr accelerates viral replication during acute infection by exploitation of proliferating CD4+ T cells in vivo.

PLoS Pathog. 2013;9(12):e1003812. doi: 10.1371/journal.ppat.1003812. Epub 2013 Dec 5. PMID: 24339781; PMCID: PMC3855622.

https://pubmed.ncbi.nlm.nih.gov/24339781/

Taura M, Kariya R, Kudo E, Goto H, Iwawaki T, Amano M, Suico MA, Kai H, Mitsuya H, Okada S.

Comparative analysis of ER stress response into HIV protease inhibitors: lopinavir but not darunavir induces potent ER stress response via ROS/JNK pathway.

Free Radic Biol Med. 2013 Dec;65:778-788. doi: 10.1016/j.freeradbiomed.2013.08.161. Epub 2013 Aug 20. PMID: 23973637.

https://pubmed.ncbi.nlm.nih.gov/23973637/

Kawano Y, Kikukawa Y, Fujiwara S, Wada N, Okuno Y, Mitsuya H, Hata H.

Hypoxia reduces CD138 expression and induces an immature and stem cell-like transcriptional program in myeloma cells.

Int J Oncol. 2013 Dec;43(6):1809-16. doi: 10.3892/ijo.2013.2134. Epub 2013 Oct 10. PMID: 24126540; PMCID: PMC3834117.

https://pubmed.ncbi.nlm.nih.gov/24126540/

Salcedo Gómez PM, Amano M, Yashchuk S, Mizuno A, Das D, Ghosh AK, Mitsuya H.

GRL-04810 and GRL-05010, difluoride-containing nonpeptidic HIV-1 protease inhibitors (PIs) that inhibit the replication of multi-PI-resistant HIV-1 in vitro and possess favorable lipophilicity that may allow blood-brain barrier penetration.

Antimicrob Agents Chemother. 2013 Dec;57(12):6110-21. doi: 10.1128/AAC.01420-13. Epub 2013 Sep 30. PMID: 24080647; PMCID: PMC3837900.

https://pubmed.ncbi.nlm.nih.gov/24080647/

Miura M, Yasunaga J, Tanabe J, Sugata K, Zhao T, Ma G, Miyazato P, Ohshima K, Kaneko A, Watanabe A, Saito A, Akari H, Matsuoka M.

Characterization of simian T-cell leukemia virus type 1 in naturally infected Japanese macaques as a model of HTLV-1 infection.

Retrovirology. 2013 Oct 24;10:118. doi: 10.1186/1742-4690-10-118. PMID: 24156738; PMCID: PMC4016002.

https://pubmed.ncbi.nlm.nih.gov/24156738/

Yedidi RS, Maeda K, Fyvie WS, Steffey M, Davis DA, Palmer I, Aoki M, Kaufman JD, Stahl SJ, Garimella H, Das D, Wingfield PT, Ghosh AK, Mitsuya H.

P2′ benzene carboxylic acid moiety is associated with decrease in cellular uptake: evaluation of novel nonpeptidic HIV-1 protease inhibitors containing P2 bis-tetrahydrofuran moiety.

Antimicrob Agents Chemother. 2013 Oct;57(10):4920-7. doi: 10.1128/AAC.00868-13. Epub 2013 Jul 22. PMID: 23877703; PMCID: PMC3811474.

https://pubmed.ncbi.nlm.nih.gov/23877703/