Kumamoto H, Fukano M, Nakano T, Iwagami K, Takeyama C, Kohgo S, Imoto S, Amano M, Kuwata-Higashi N, Aoki M, Abe H, Mitsuya H, Fukuhara K, Haraguchi K.

Diastereoselective Synthesis of 6″-(Z)- and 6″-(E)-Fluoro Analogues of Anti-hepatitis B Virus Agent Entecavir and Its Evaluation of the Activity and Toxicity Profile of the Diastereomers.

J Org Chem. 2016 Apr 1;81(7):2827-36. doi: 10.1021/acs.joc.6b00105. Epub 2016 Mar 24. PMID: 27009432.

https://pubmed.ncbi.nlm.nih.gov/27009432/

Haji S, Kiyasu J, Choi I, Suehiro Y, Toyoda K, Tsuda M, Takamatsu A, Nakashima Y, Miyoshi H, Shiratsuchi M, Yamasaki S, Uike N, Abe Y.

Administration of an anti-CC chemokine receptor 4 monoclonal antibody, mogamulizumab, before allogeneic bone marrow transplantation for adult T-cell leukemia/lymphoma.

Bone Marrow Transplant. 2016 Mar;51(3):432-4. doi: 10.1038/bmt.2015.254. Epub 2015 Nov 2. PMID: 26524267.

https://pubmed.ncbi.nlm.nih.gov/26524267/

Doi M, Murai I, Kunisue S, Setsu G, Uchio N, Tanaka R, Kobayashi S, Shimatani H, Hayashi H, Chao HW, Nakagawa Y, Takahashi Y, Hotta Y, Yasunaga J, Matsuoka M, Hastings MH, Kiyonari H, Okamura H.

Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour.

Nat Commun. 2016 Feb 17;7:10583. doi: 10.1038/ncomms10583. PMID: 26882873; PMCID: PMC4757782.

https://pubmed.ncbi.nlm.nih.gov/26882873/

Fuji S, Fujiwara H, Nakano N, Wake A, Inoue Y, Fukuda T, Hidaka M, Moriuchi Y, Miyamoto T, Uike N, Taguchi J, Eto T, Tomoyose T, Kondo T, Yamanoha A, Ichinohe T, Atsuta Y, Utsunomiya A; ATL Working Group of the Japan Society for Hematopoietic Cell Transplantation.

Early application of related SCT might improve clinical outcome in adult T-cell leukemia/lymphoma.

Bone Marrow Transplant. 2016 Feb;51(2):205-11. doi: 10.1038/bmt.2015.265. Epub 2015 Nov 2. PMID: 26524263.

https://pubmed.ncbi.nlm.nih.gov/26524263/

Endo S, Amano M, Nishimura N, Ueno N, Ueno S, Yuki H, Fujiwara S, Wada N, Hirata S, Hata H, Mitsuya H, Okuno Y.

Immunomodulatory drugs act as inhibitors of DNA methyltransferases and induce PU.1 up-regulation in myeloma cells.

Biochem Biophys Res Commun. 2016 Jan 8;469(2):236-42. doi: 10.1016/j.bbrc.2015.11.116. Epub 2015 Nov 30. PMID: 26657848.

https://pubmed.ncbi.nlm.nih.gov/26657848/

Yasuma K, Yasunaga J, Takemoto K, Sugata K, Mitobe Y, Takenouchi N, Nakagawa M, Suzuki Y, Matsuoka M.

HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT).

PLoS Pathog. 2016 Jan 6;12(1):e1005372. doi: 10.1371/journal.ppat.1005372. PMID: 26735971; PMCID: PMC4703212.

https://pubmed.ncbi.nlm.nih.gov/26735971/

Glavey SV, Manier S, Sacco A, Salem K, Kawano Y, Bouyssou J, Ghobrial IM, Roccaro AM.

Epigenetics in Multiple Myeloma.

Cancer Treat Res. 2016;169:35-49. doi: 10.1007/978-3-319-40320-5_4. PMID: 27696257.

Moschetta M, Kawano Y, Podar K.

Targeting the Bone Marrow Microenvironment.

Cancer Treat Res. 2016;169:63-102. doi: 10.1007/978-3-319-40320-5_6. PMID: 27696259.

Makita S, Fuji S, Takano K, Tanaka T, Inoue Y, Ito R, Ito A, Hayashi Y, Tajima K, Okinaka K, Kurosawa S, Kim SW, Yamashita T, Tanosaki R, Tobinai K, Fukuda T.

Clinical Outcomes after Allogeneic Stem Cell Transplantation for Adult Lymphoblastic Lymphoma.

J Clin Exp Hematop. 2016;56(1):28-33. doi: 10.3960/jslrt.56.28. PMID: 27334855; PMCID: PMC6144282.

https://pubmed.ncbi.nlm.nih.gov/27334855/

Kikukawa Y, Hata H, Ueda M, Yamashita T, Nasu S, Ide K, Ueno S, Ando Y, Mitsuya H, Okuno Y.

Successful Treatment of Amyloid Light-chain Amyloidosis in a Charcot-Marie-Tooth Disease Patient with Lenalidomide, Cyclophosphamide, and Dexamethasone.

Intern Med. 2016;55(18):2707-12. doi: 10.2169/internalmedicine.55.5815. Epub 2016 Sep 15. PMID: 27629972.

https://pubmed.ncbi.nlm.nih.gov/27629972/

Ghosh AK, Martyr CD, Kassekert LA, Nyalapatla PR, Steffey M, Agniswamy J, Wang YF, Weber IT, Amano M, Mitsuya H.

Design, synthesis, biological evaluation and X-ray structural studies of HIV-1 protease inhibitors containing substituted fused-tetrahydropyranyl tetrahydrofuran as P2-ligands.

Org Biomol Chem. 2015 Dec 28;13(48):11607-21. doi: 10.1039/c5ob01930c. Epub 2015 Oct 14. PMID: 26462551; PMCID: PMC4666783.

https://pubmed.ncbi.nlm.nih.gov/26462551/

Aoki M, Hayashi H, Yedidi RS, Martyr CD, Takamatsu Y, Aoki-Ogata H, Nakamura T, Nakata H, Das D, Yamagata Y, Ghosh AK, Mitsuya H.

C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir.

J Virol. 2015 Nov 18;90(5):2180-94. doi: 10.1128/JVI.01829-15. PMID: 26581995; PMCID: PMC4810716.

https://pubmed.ncbi.nlm.nih.gov/26581995/

Kataoka K, Nagata Y, Kitanaka A, Shiraishi Y, Shimamura T, Yasunaga J, Totoki Y, Chiba K, Sato-Otsubo A, Nagae G, Ishii R, Muto S, Kotani S, Watatani Y, Takeda J, Sanada M, Tanaka H, Suzuki H, Sato Y, Shiozawa Y, Yoshizato T, Yoshida K, Makishima H, Iwanaga M, Ma G, Nosaka K, Hishizawa M, Itonaga H, Imaizumi Y, Munakata W, Ogasawara H, Sato T, Sasai K, Muramoto K, Penova M, Kawaguchi T, Nakamura H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda T, Nakamaki T, Ishiyama K, Miyawaki S, Yoon SS, Tobinai K, Miyazaki Y, Takaori-Kondo A, Matsuda F, Takeuchi K, Nureki O, Aburatani H, Watanabe T, Shibata T, Matsuoka M, Miyano S, Shimoda K, Ogawa S.

Integrated molecular analysis of adult T cell leukemia/lymphoma.

Nat Genet. 2015 Nov;47(11):1304-15. doi: 10.1038/ng.3415. Epub 2015 Oct 5. PMID: 26437031.

https://pubmed.ncbi.nlm.nih.gov/26437031/

Shimura K, Miyazato P, Oishi S, Fujii N, Matsuoka M.

Impact of HIV-1 infection pathways on susceptibility to antiviral drugs and on virus spread.

Virology. 2015 Oct;484:364-76. doi: 10.1016/j.virol.2015.06.029. Epub 2015 Jul 15. PMID: 26186575.

https://pubmed.ncbi.nlm.nih.gov/26186575/

Mitobe Y, Yasunaga J, Furuta R, Matsuoka M.

HTLV-1 bZIP Factor RNA and Protein Impart Distinct Functions on T-cell Proliferation and Survival.

Cancer Res. 2015 Oct 1;75(19):4143-52. doi: 10.1158/0008-5472.CAN-15-0942. Epub 2015 Sep 17. PMID: 26383166.

https://pubmed.ncbi.nlm.nih.gov/26383166/

Takamatsu Y, Tanaka Y, Kohgo S, Murakami S, Singh K, Das D, Venzon DJ, Amano M, Higashi-Kuwata N, Aoki M, Delino NS, Hayashi S, Takahashi S, Sukenaga Y, Haraguchi K, Sarafianos SG, Maeda K, Mitsuya H.

4′-modified nucleoside analogs: potent inhibitors active against entecavir-resistant hepatitis B virus.

Hepatology. 2015 Oct;62(4):1024-36. doi: 10.1002/hep.27962. Epub 2015 Aug 25. PMID: 26122273; PMCID: PMC4589464.

https://pubmed.ncbi.nlm.nih.gov/26122273/

Sato K, Kobayashi T, Misawa N, Yoshikawa R, Takeuchi JS, Miura T, Okamoto M, Yasunaga J, Matsuoka M, Ito M, Miyazawa T, Koyanagi Y.

Experimental evaluation of the zoonotic infection potency of simian retrovirus type 4 using humanized mouse model.

Sci Rep. 2015 Sep 14;5:14040. doi: 10.1038/srep14040. PMID: 26364986; PMCID: PMC4568461.

https://pubmed.ncbi.nlm.nih.gov/26364986/

Ghosh AK, Martyr CD, Osswald HL, Sheri VR, Kassekert LA, Chen S, Agniswamy J, Wang YF, Hayashi H, Aoki M, Weber IT, Mitsuya H.

Design of HIV-1 Protease Inhibitors with Amino-bis-tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation, and Protein-Ligand X-ray Studies.

J Med Chem. 2015 Sep 10;58(17):6994-7006. doi: 10.1021/acs.jmedchem.5b00900. Epub 2015 Aug 25. PMID: 26306007; PMCID: PMC4765732.

https://pubmed.ncbi.nlm.nih.gov/26306007/

Sugata K, Yasunaga J, Mitobe Y, Miura M, Miyazato P, Kohara M, Matsuoka M.

Protective effect of cytotoxic T lymphocytes targeting HTLV-1 bZIP factor.

Blood. 2015 Aug 27;126(9):1095-105. doi: 10.1182/blood-2015-04-641118. Epub 2015 Jun 10. PMID: 26063164.

https://pubmed.ncbi.nlm.nih.gov/26063164/

Mitagami Y, Yasunaga J, Kinosada H, Ohshima K, Matsuoka M.

Interferon-γ Promotes Inflammation and Development of T-Cell Lymphoma in HTLV-1 bZIP Factor Transgenic Mice.

PLoS Pathog. 2015 Aug 21;11(8):e1005120. doi: 10.1371/journal.ppat.1005120. Erratum in: PLoS Pathog. 2015 Oct;11(10):e1005214. PMID: 26296091; PMCID: PMC4546626.

https://pubmed.ncbi.nlm.nih.gov/26296091/

Ghosh AK, Yu X, Osswald HL, Agniswamy J, Wang YF, Amano M, Weber IT, Mitsuya H.

Structure-based design of potent HIV-1 protease inhibitors with modified P1-biphenyl ligands: synthesis, biological evaluation, and enzyme-inhibitor X-ray structural studies.

J Med Chem. 2015 Jul 9;58(13):5334-43. doi: 10.1021/acs.jmedchem.5b00676. Epub 2015 Jun 24. PMID: 26107245; PMCID: PMC4765733.

https://pubmed.ncbi.nlm.nih.gov/26107245/

Kinpara S, Ito S, Takahata T, Saitoh Y, Hasegawa A, Kijiyama M, Utsunomiya A, Masuda M, Miyazaki Y, Matsuoka M, Nakamura M, Yamaoka S, Masuda T, Kannagi M.

Involvement of double-stranded RNA-dependent protein kinase and antisense viral RNA in the constitutive NFκB activation in adult T-cell leukemia/lymphoma cells.

Leukemia. 2015 Jun;29(6):1425-9. doi: 10.1038/leu.2015.1. Epub 2014 Jan 8. PMID: 25567137.

https://pubmed.ncbi.nlm.nih.gov/25567137/

Suehiro Y, Hasegawa A, Iino T, Sasada A, Watanabe N, Matsuoka M, Takamori A, Tanosaki R, Utsunomiya A, Choi I, Fukuda T, Miura O, Takaishi S, Teshima T, Akashi K, Kannagi M, Uike N, Okamura J.

Clinical outcomes of a novel therapeutic vaccine with Tax peptide-pulsed dendritic cells for adult T cell leukaemia/lymphoma in a pilot study.

Br J Haematol. 2015 May;169(3):356-67. doi: 10.1111/bjh.13302. Epub 2015 Jan 22. PMID: 25612920.

https://pubmed.ncbi.nlm.nih.gov/25612920/

Amano M, Tojo Y, Salcedo-Gómez PM, Parham GL, Nyalapatla PR, Das D, Ghosh AK, Mitsuya H.

A novel tricyclic ligand-containing nonpeptidic HIV-1 protease inhibitor, GRL-0739, effectively inhibits the replication of multidrug-resistant HIV-1 variants and has a desirable central nervous system penetration property in vitro.

Antimicrob Agents Chemother. 2015 May;59(5):2625-35. doi: 10.1128/AAC.04757-14. Epub 2015 Feb 17. PMID: 25691652; PMCID: PMC4394833.

https://pubmed.ncbi.nlm.nih.gov/25691652/