Aoki M, Hayashi H, Yedidi RS, Martyr CD, Takamatsu Y, Aoki-Ogata H, Nakamura T, Nakata H, Das D, Yamagata Y, Ghosh AK, Mitsuya H.

C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir.

J Virol. 2015 Nov 18;90(5):2180-94. doi: 10.1128/JVI.01829-15. PMID: 26581995; PMCID: PMC4810716.

https://pubmed.ncbi.nlm.nih.gov/26581995/

Kataoka K, Nagata Y, Kitanaka A, Shiraishi Y, Shimamura T, Yasunaga J, Totoki Y, Chiba K, Sato-Otsubo A, Nagae G, Ishii R, Muto S, Kotani S, Watatani Y, Takeda J, Sanada M, Tanaka H, Suzuki H, Sato Y, Shiozawa Y, Yoshizato T, Yoshida K, Makishima H, Iwanaga M, Ma G, Nosaka K, Hishizawa M, Itonaga H, Imaizumi Y, Munakata W, Ogasawara H, Sato T, Sasai K, Muramoto K, Penova M, Kawaguchi T, Nakamura H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda T, Nakamaki T, Ishiyama K, Miyawaki S, Yoon SS, Tobinai K, Miyazaki Y, Takaori-Kondo A, Matsuda F, Takeuchi K, Nureki O, Aburatani H, Watanabe T, Shibata T, Matsuoka M, Miyano S, Shimoda K, Ogawa S.

Integrated molecular analysis of adult T cell leukemia/lymphoma.

Nat Genet. 2015 Nov;47(11):1304-15. doi: 10.1038/ng.3415. Epub 2015 Oct 5. PMID: 26437031.

https://pubmed.ncbi.nlm.nih.gov/26437031/

Shimura K, Miyazato P, Oishi S, Fujii N, Matsuoka M.

Impact of HIV-1 infection pathways on susceptibility to antiviral drugs and on virus spread.

Virology. 2015 Oct;484:364-76. doi: 10.1016/j.virol.2015.06.029. Epub 2015 Jul 15. PMID: 26186575.

https://pubmed.ncbi.nlm.nih.gov/26186575/

Mitobe Y, Yasunaga J, Furuta R, Matsuoka M.

HTLV-1 bZIP Factor RNA and Protein Impart Distinct Functions on T-cell Proliferation and Survival.

Cancer Res. 2015 Oct 1;75(19):4143-52. doi: 10.1158/0008-5472.CAN-15-0942. Epub 2015 Sep 17. PMID: 26383166.

https://pubmed.ncbi.nlm.nih.gov/26383166/

Takamatsu Y, Tanaka Y, Kohgo S, Murakami S, Singh K, Das D, Venzon DJ, Amano M, Higashi-Kuwata N, Aoki M, Delino NS, Hayashi S, Takahashi S, Sukenaga Y, Haraguchi K, Sarafianos SG, Maeda K, Mitsuya H.

4′-modified nucleoside analogs: potent inhibitors active against entecavir-resistant hepatitis B virus.

Hepatology. 2015 Oct;62(4):1024-36. doi: 10.1002/hep.27962. Epub 2015 Aug 25. PMID: 26122273; PMCID: PMC4589464.

https://pubmed.ncbi.nlm.nih.gov/26122273/

Sato K, Kobayashi T, Misawa N, Yoshikawa R, Takeuchi JS, Miura T, Okamoto M, Yasunaga J, Matsuoka M, Ito M, Miyazawa T, Koyanagi Y.

Experimental evaluation of the zoonotic infection potency of simian retrovirus type 4 using humanized mouse model.

Sci Rep. 2015 Sep 14;5:14040. doi: 10.1038/srep14040. PMID: 26364986; PMCID: PMC4568461.

https://pubmed.ncbi.nlm.nih.gov/26364986/

Ghosh AK, Martyr CD, Osswald HL, Sheri VR, Kassekert LA, Chen S, Agniswamy J, Wang YF, Hayashi H, Aoki M, Weber IT, Mitsuya H.

Design of HIV-1 Protease Inhibitors with Amino-bis-tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation, and Protein-Ligand X-ray Studies.

J Med Chem. 2015 Sep 10;58(17):6994-7006. doi: 10.1021/acs.jmedchem.5b00900. Epub 2015 Aug 25. PMID: 26306007; PMCID: PMC4765732.

https://pubmed.ncbi.nlm.nih.gov/26306007/

Sugata K, Yasunaga J, Mitobe Y, Miura M, Miyazato P, Kohara M, Matsuoka M.

Protective effect of cytotoxic T lymphocytes targeting HTLV-1 bZIP factor.

Blood. 2015 Aug 27;126(9):1095-105. doi: 10.1182/blood-2015-04-641118. Epub 2015 Jun 10. PMID: 26063164.

https://pubmed.ncbi.nlm.nih.gov/26063164/

Mitagami Y, Yasunaga J, Kinosada H, Ohshima K, Matsuoka M.

Interferon-γ Promotes Inflammation and Development of T-Cell Lymphoma in HTLV-1 bZIP Factor Transgenic Mice.

PLoS Pathog. 2015 Aug 21;11(8):e1005120. doi: 10.1371/journal.ppat.1005120. Erratum in: PLoS Pathog. 2015 Oct;11(10):e1005214. PMID: 26296091; PMCID: PMC4546626.

https://pubmed.ncbi.nlm.nih.gov/26296091/

Ghosh AK, Yu X, Osswald HL, Agniswamy J, Wang YF, Amano M, Weber IT, Mitsuya H.

Structure-based design of potent HIV-1 protease inhibitors with modified P1-biphenyl ligands: synthesis, biological evaluation, and enzyme-inhibitor X-ray structural studies.

J Med Chem. 2015 Jul 9;58(13):5334-43. doi: 10.1021/acs.jmedchem.5b00676. Epub 2015 Jun 24. PMID: 26107245; PMCID: PMC4765733.

https://pubmed.ncbi.nlm.nih.gov/26107245/

Kinpara S, Ito S, Takahata T, Saitoh Y, Hasegawa A, Kijiyama M, Utsunomiya A, Masuda M, Miyazaki Y, Matsuoka M, Nakamura M, Yamaoka S, Masuda T, Kannagi M.

Involvement of double-stranded RNA-dependent protein kinase and antisense viral RNA in the constitutive NFκB activation in adult T-cell leukemia/lymphoma cells.

Leukemia. 2015 Jun;29(6):1425-9. doi: 10.1038/leu.2015.1. Epub 2014 Jan 8. PMID: 25567137.

https://pubmed.ncbi.nlm.nih.gov/25567137/

Suehiro Y, Hasegawa A, Iino T, Sasada A, Watanabe N, Matsuoka M, Takamori A, Tanosaki R, Utsunomiya A, Choi I, Fukuda T, Miura O, Takaishi S, Teshima T, Akashi K, Kannagi M, Uike N, Okamura J.

Clinical outcomes of a novel therapeutic vaccine with Tax peptide-pulsed dendritic cells for adult T cell leukaemia/lymphoma in a pilot study.

Br J Haematol. 2015 May;169(3):356-67. doi: 10.1111/bjh.13302. Epub 2015 Jan 22. PMID: 25612920.

https://pubmed.ncbi.nlm.nih.gov/25612920/

Amano M, Tojo Y, Salcedo-Gómez PM, Parham GL, Nyalapatla PR, Das D, Ghosh AK, Mitsuya H.

A novel tricyclic ligand-containing nonpeptidic HIV-1 protease inhibitor, GRL-0739, effectively inhibits the replication of multidrug-resistant HIV-1 variants and has a desirable central nervous system penetration property in vitro.

Antimicrob Agents Chemother. 2015 May;59(5):2625-35. doi: 10.1128/AAC.04757-14. Epub 2015 Feb 17. PMID: 25691652; PMCID: PMC4394833.

https://pubmed.ncbi.nlm.nih.gov/25691652/

Okazaki S, Oishi S, Mizuhara T, Shimura K, Murayama H, Ohno H, Matsuoka M, Fujii N.

Investigations of possible prodrug structures for 2-(2-mercaptophenyl)tetrahydropyrimidines: reductive conversion from anti-HIV agents with pyrimidobenzothiazine and isothiazolopyrimidine scaffolds.

Org Biomol Chem. 2015 Apr 28;13(16):4706-13. doi: 10.1039/c5ob00301f. PMID: 25800792.

https://pubmed.ncbi.nlm.nih.gov/25800792/

Fujiwara S, Wada N, Kawano Y, Okuno Y, Kikukawa Y, Endo S, Nishimura N, Ueno N, Mitsuya H, Hata H.

Lactate, a putative survival factor for myeloma cells, is incorporated by myeloma cells through monocarboxylate transporters 1.

Exp Hematol Oncol. 2015 Apr 21;4:12. doi: 10.1186/s40164-015-0008-z. PMID: 25909034; PMCID: PMC4407384.

https://pubmed.ncbi.nlm.nih.gov/25909034/

Furuta RA, Ma G, Matsuoka M, Otani S, Matsukura H, Hirayama F.

Reevaluation of confirmatory tests for human T-cell leukemia virus Type 1 using a luciferase immunoprecipitation system in blood donors.

Transfusion. 2015 Apr;55(4):880-9. doi: 10.1111/trf.12911. Epub 2014 Nov 2. PMID: 25363675.

https://pubmed.ncbi.nlm.nih.gov/25363675/

Okazaki S, Mizuhara T, Shimura K, Murayama H, Ohno H, Oishi S, Matsuoka M, Fujii N.

Identification of anti-HIV agents with a novel benzo[4,5]isothiazolo[2,3-a]pyrimidine scaffold.

Bioorg Med Chem. 2015 Apr 1;23(7):1447-52. doi: 10.1016/j.bmc.2015.02.015. Epub 2015 Feb 16. PMID: 25744188.

https://pubmed.ncbi.nlm.nih.gov/25744188/

Takachi T, Takahashi M, Takahashi-Yoshita M, Higuchi M, Obata M, Mishima Y, Okuda S, Tanaka Y, Matsuoka M, Saitoh A, Green PL, Fujii M.

Human T-cell leukemia virus type 1 Tax oncoprotein represses the expression of the BCL11B tumor suppressor in T-cells.

Cancer Sci. 2015 Apr;106(4):461-5. doi: 10.1111/cas.12618. Epub 2015 Mar 16. PMID: 25613934; PMCID: PMC4409891.

https://pubmed.ncbi.nlm.nih.gov/25613934/

Das D, Maeda K, Hayashi Y, Gavande N, Desai DV, Chang SB, Ghosh AK, Mitsuya H.

Insights into the mechanism of inhibition of CXCR4: identification of Piperidinylethanamine analogs as anti-HIV-1 inhibitors.

Antimicrob Agents Chemother. 2015 Apr;59(4):1895-904. doi: 10.1128/AAC.04654-14. Epub 2015 Jan 12. PMID: 25583709; PMCID: PMC4356787.

https://pubmed.ncbi.nlm.nih.gov/25583709/

Wada N, Kawano Y, Fujiwara S, Kikukawa Y, Okuno Y, Tasaki M, Ueda M, Ando Y, Yoshinaga K, Ri M, Iida S, Nakashima T, Shiotsu Y, Mitsuya H, Hata H.

Shikonin, dually functions as a proteasome inhibitor and a necroptosis inducer in multiple myeloma cells.

Int J Oncol. 2015 Mar;46(3):963-72. doi: 10.3892/ijo.2014.2804. Epub 2014 Dec 19. PMID: 25530098; PMCID: PMC4324584.

https://pubmed.ncbi.nlm.nih.gov/25530098/

Haji S, Abe Y, Tsuda M, Toyoda K, Choi I, Suehiro Y, Shiratsuchi M, Kiyasu J, Uike N.

[CD20-positive plasma cell myeloma with lymphoplasmacytoid appearance mimicking low-grade B-cell lymphoma].

Rinsho Ketsueki. 2015 Mar;56(3):335-8. Japanese. doi: 10.11406/rinketsu.56.335. PMID: 25876789.

https://pubmed.ncbi.nlm.nih.gov/25876789/

Ma G, Yasunaga J, Akari H, Matsuoka M.

TCF1 and LEF1 act as T-cell intrinsic HTLV-1 antagonists by targeting Tax.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2216-21. doi: 10.1073/pnas.1419198112. Epub 2015 Feb 2. PMID: 25646419; PMCID: PMC4343127.

https://pubmed.ncbi.nlm.nih.gov/25646419/

Kikukawa Y, Yuki H, Hirata S, Ide K, Nakata H, Miyakawa T, Matsuno N, Nosaka K, Yonemura Y, Kawaguchi T, Hata H, Mitsuya H, Okuno Y.

Combined use of bortezomib, cyclophosphamide, and dexamethasone induces favorable hematological and organ responses in Japanese patients with amyloid light-chain amyloidosis: a single-institution retrospective study.

Int J Hematol. 2015 Feb;101(2):133-9. doi: 10.1007/s12185-014-1705-9. Epub 2014 Nov 28. PMID: 25430082.

https://pubmed.ncbi.nlm.nih.gov/25430082/

Ghosh AK, Yashchuk S, Mizuno A, Chakraborty N, Agniswamy J, Wang YF, Aoki M, Gomez PM, Amano M, Weber IT, Mitsuya H.

Design of gem-difluoro-bis-tetrahydrofuran as P2 ligand for HIV-1 protease inhibitors to improve brain penetration: synthesis, X-ray studies, and biological evaluation.

ChemMedChem. 2015 Jan;10(1):107-15. doi: 10.1002/cmdc.201402358. Epub 2014 Oct 21. PMID: 25336073; PMCID: PMC4419590.

https://pubmed.ncbi.nlm.nih.gov/25336073/