KUMAMOTO University

R

研究業績RESEARCH ACHIEVEMENTS

  1. Kataoka K, Nagata Y, Kitanaka A, Shiraishi Y, Shimamura T, Yasunaga J, Totoki Y, Chiba K, Sato-Otsubo A, Nagae G, Ishii R, Muto S, Kotani S, Watatani Y, Takeda J, Sanada M, Tanaka H, Suzuki H, Sato Y, Shiozawa Y, Yoshizato T, Yoshida K, Makishima H, Iwanaga M, Ma G, Nosaka K, Hishizawa M, Itonaga H, Imaizumi Y, Munakata W, Ogasawara H, Sato T, Sasai K, Muramoto K, Penova M, Kawaguchi T, Nakamura H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda T, Nakamaki T, Ishiyama K, Miyawaki S, Yoon SS, Tobinai K, Miyazaki Y, Takaori-Kondo A, Matsuda F, Takeuchi K, Nureki O, Aburatani H, Watanabe T, Shibata T, Matsuoka M, Miyano S, Shimoda K, Ogawa S.

    Integrated molecular analysis of adult T cell leukemia/lymphoma.

    Nat Genet. 2015 Nov;47(11):1304-15. doi: 10.1038/ng.3415. Epub 2015 Oct 5. PMID: 26437031.

  2. Mitobe Y, Yasunaga J, Furuta R, Matsuoka M.

    HTLV-1 bZIP Factor RNA and Protein Impart Distinct Functions on T-cell Proliferation and Survival.

    Cancer Res. 2015 Oct 1;75(19):4143-52. doi: 10.1158/0008-5472.CAN-15-0942. Epub 2015 Sep 17. PMID: 26383166.

  3. Kikukawa Y, Yamamura-Fujimoto A, Endo S, Miyagawa E, Kawano Y, Ueno S, Mitsuya H, Hata H, Okuno Y.

    Successful Treatment of Bing-Neel Syndrome Accompanying Waldenström’s Macroglobulinemia with R-MPV: A Case Report.

    J Clin Exp Hematop. 2015;55(2):113-9. doi: 10.3960/jslrt.55.113. PMID: 26490525.

  4. Hirano T, Higuchi Y, Yuki H, Hirata S, Nosaka K, Ishii N, Hashimoto T, Mitsuya H, Okuno Y.

    Rituximab Monotherapy and Rituximab-Containing Chemotherapy Were Effective for Paraneoplastic Pemphigus Accompanying Follicular Lymphoma, but not for Subsequent Bronchiolitis Obliterans.

    J Clin Exp Hematop. 2015;55(2):83-8. doi: 10.3960/jslrt.55.83. PMID: 26490520.

  5. Das D, Maeda K, Hayashi Y, Gavande N, Desai DV, Chang SB, Ghosh AK, Mitsuya H.

    Insights into the mechanism of inhibition of CXCR4: identification of Piperidinylethanamine analogs as anti-HIV-1 inhibitors.

    Antimicrob Agents Chemother. 2015 Apr;59(4):1895-904. doi: 10.1128/AAC.04654-14. Epub 2015 Jan 12. PMID: 25583709; PMCID: PMC4356787.

  6. Kikukawa Y, Yuki H, Hirata S, Ide K, Nakata H, Miyakawa T, Matsuno N, Nosaka K, Yonemura Y, Kawaguchi T, Hata H, Mitsuya H, Okuno Y.

    Combined use of bortezomib, cyclophosphamide, and dexamethasone induces favorable hematological and organ responses in Japanese patients with amyloid light-chain amyloidosis: a single-institution retrospective study.

    Int J Hematol. 2015 Feb;101(2):133-9. doi: 10.1007/s12185-014-1705-9. Epub 2014 Nov 28. PMID: 25430082.

  7. Aoki M, Hayashi H, Yedidi RS, Martyr CD, Takamatsu Y, Aoki-Ogata H, Nakamura T, Nakata H, Das D, Yamagata Y, Ghosh AK, Mitsuya H.

    C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir.

    J Virol. 2015 Nov 18;90(5):2180-94. doi: 10.1128/JVI.01829-15. PMID: 26581995; PMCID: PMC4810716.

  8. Ghosh AK, Yu X, Osswald HL, Agniswamy J, Wang YF, Amano M, Weber IT, Mitsuya H.

    Structure-based design of potent HIV-1 protease inhibitors with modified P1-biphenyl ligands: synthesis, biological evaluation, and enzyme-inhibitor X-ray structural studies.

    J Med Chem. 2015 Jul 9;58(13):5334-43. doi: 10.1021/acs.jmedchem.5b00676. Epub 2015 Jun 24. PMID: 26107245; PMCID: PMC4765733.

  9. Imoto S, Kohgo S, Tokuda R, Kumamoto H, Aoki M, Amano M, Kuwata-Higashi N, Mitsuya H, Haraguchi K.

    Design, Synthesis, and Evaluation of Anti-HBV Activity of Hybrid Molecules of Entecavir and Adefovir: Exomethylene Acycloguanine Nucleosides and Their Monophosphate Derivatives.

    Nucleosides Nucleotides Nucleic Acids. 2015;34(8):590-602. doi: 10.1080/15257770.2015.1037456. PMID: 26167667.

  10. Ghosh AK, Martyr CD, Osswald HL, Sheri VR, Kassekert LA, Chen S, Agniswamy J, Wang YF, Hayashi H, Aoki M, Weber IT, Mitsuya H.

    Design of HIV-1 Protease Inhibitors with Amino-bis-tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation, and Protein-Ligand X-ray Studies.

    J Med Chem. 2015 Sep 10;58(17):6994-7006. doi: 10.1021/acs.jmedchem.5b00900. Epub 2015 Aug 25. PMID: 26306007; PMCID: PMC4765732.

  11. Ghosh AK, Martyr CD, Kassekert LA, Nyalapatla PR, Steffey M, Agniswamy J, Wang YF, Weber IT, Amano M, Mitsuya H.

    Design, synthesis, biological evaluation and X-ray structural studies of HIV-1 protease inhibitors containing substituted fused-tetrahydropyranyl tetrahydrofuran as P2-ligands.

    Org Biomol Chem. 2015 Dec 28;13(48):11607-21. doi: 10.1039/c5ob01930c. Epub 2015 Oct 14. PMID: 26462551; PMCID: PMC4666783.

  12. Sugata K, Yasunaga J, Mitobe Y, Miura M, Miyazato P, Kohara M, Matsuoka M.

    Protective effect of cytotoxic T lymphocytes targeting HTLV-1 bZIP factor.

    Blood. 2015 Aug 27;126(9):1095-105. doi: 10.1182/blood-2015-04-641118. Epub 2015 Jun 10. PMID: 26063164.

  13. Takamatsu Y, Tanaka Y, Kohgo S, Murakami S, Singh K, Das D, Venzon DJ, Amano M, Higashi-Kuwata N, Aoki M, Delino NS, Hayashi S, Takahashi S, Sukenaga Y, Haraguchi K, Sarafianos SG, Maeda K, Mitsuya H.

    4′-modified nucleoside analogs: potent inhibitors active against entecavir-resistant hepatitis B virus.

    Hepatology. 2015 Oct;62(4):1024-36. doi: 10.1002/hep.27962. Epub 2015 Aug 25. PMID: 26122273; PMCID: PMC4589464.

  14. Wada N, Kawano Y, Fujiwara S, Kikukawa Y, Okuno Y, Tasaki M, Ueda M, Ando Y, Yoshinaga K, Ri M, Iida S, Nakashima T, Shiotsu Y, Mitsuya H, Hata H.

    Shikonin, dually functions as a proteasome inhibitor and a necroptosis inducer in multiple myeloma cells.

    Int J Oncol. 2015 Mar;46(3):963-72. doi: 10.3892/ijo.2014.2804. Epub 2014 Dec 19. PMID: 25530098; PMCID: PMC4324584.

  15. Fujiwara S, Wada N, Kawano Y, Okuno Y, Kikukawa Y, Endo S, Nishimura N, Ueno N, Mitsuya H, Hata H.

    Lactate, a putative survival factor for myeloma cells, is incorporated by myeloma cells through monocarboxylate transporters 1.

    Exp Hematol Oncol. 2015 Apr 21;4:12. doi: 10.1186/s40164-015-0008-z. PMID: 25909034; PMCID: PMC4407384.

  16. Amano M, Tojo Y, Salcedo-Gómez PM, Parham GL, Nyalapatla PR, Das D, Ghosh AK, Mitsuya H.

    A novel tricyclic ligand-containing nonpeptidic HIV-1 protease inhibitor, GRL-0739, effectively inhibits the replication of multidrug-resistant HIV-1 variants and has a desirable central nervous system penetration property in vitro.

    Antimicrob Agents Chemother. 2015 May;59(5):2625-35. doi: 10.1128/AAC.04757-14. Epub 2015 Feb 17. PMID: 25691652; PMCID: PMC4394833.

  17. Mitagami Y, Yasunaga J, Kinosada H, Ohshima K, Matsuoka M.

    Interferon-γ Promotes Inflammation and Development of T-Cell Lymphoma in HTLV-1 bZIP Factor Transgenic Mice.

    PLoS Pathog. 2015 Aug 21;11(8):e1005120. doi: 10.1371/journal.ppat.1005120. Erratum in: PLoS Pathog. 2015 Oct;11(10):e1005214. PMID: 26296091; PMCID: PMC4546626.

  18. Haji S, Abe Y, Tsuda M, Toyoda K, Choi I, Suehiro Y, Shiratsuchi M, Kiyasu J, Uike N.

    [CD20-positive plasma cell myeloma with lymphoplasmacytoid appearance mimicking low-grade B-cell lymphoma].

    Rinsho Ketsueki. 2015 Mar;56(3):335-8. Japanese. doi: 10.11406/rinketsu.56.335. PMID: 25876789.

  19. Matsuzawa T, Kawamura T, Ogawa Y, Maeda K, Nakata H, Moriishi K, Koyanagi Y, Gatanaga H, Shimada S, Mitsuya H.

    EFdA, a reverse transcriptase inhibitor, potently blocks HIV-1 ex vivo infection of Langerhans cells within epithelium.

    J Invest Dermatol. 2014 Apr;134(4):1158-1161. doi: 10.1038/jid.2013.467. Epub 2013 Nov 11. PMID: 24384694.

  20. Zhang W, Parniak MA, Mitsuya H, Sarafianos SG, Graebing PW, Rohan LC.

    Preformulation studies of EFdA, a novel nucleoside reverse transcriptase inhibitor for HIV prevention.

    Drug Dev Ind Pharm. 2014 Aug;40(8):1101-11. doi: 10.3109/03639045.2013.809535. Epub 2013 Jul 10. PMID: 23841536; PMCID: PMC4136418.

  21. Tanaka-Nakanishi A, Yasunaga J, Takai K, Matsuoka M.

    HTLV-1 bZIP factor suppresses apoptosis by attenuating the function of FoxO3a and altering its localization.

    Cancer Res. 2014 Jan 1;74(1):188-200. doi: 10.1158/0008-5472.CAN-13-0436. Epub 2013 Oct 31. PMID: 24177179.

  22. Azuma Y, Kükenshöner T, Ma G, Yasunaga J, Imanishi M, Tanaka G, Nakase I, Maruno T, Kobayashi Y, Arndt KM, Matsuoka M, Futaki S.

    Controlling leucine-zipper partner recognition in cells through modification of a-g interactions.

    Chem Commun (Camb). 2014 Jun 18;50(48):6364-7. doi: 10.1039/c4cc00555d. PMID: 24803110.

  23. Zhao T, Satou Y, Matsuoka M.

    Development of T cell lymphoma in HTLV-1 bZIP factor and Tax double transgenic mice.

    Arch Virol. 2014 Jul;159(7):1849-56. doi: 10.1007/s00705-014-2099-y. Epub 2014 May 13. PMID: 24818712.

  24. Cook LB, Melamed A, Niederer H, Valganon M, Laydon D, Foroni L, Taylor GP, Matsuoka M, Bangham CR.

    The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma.

    Blood. 2014 Jun 19;123(25):3925-31. doi: 10.1182/blood-2014-02-553602. Epub 2014 Apr 15. PMID: 24735963; PMCID: PMC4064332.

CONTACT US

C

  • 患者様へ

    外来診療の方は外来予約センターより
    ご予約をお願いいたします。
    外来予約センター

  • 学生・研修医・医療関係者の方へ

    TEL
    096-373-5156
    FAX
    096-373-5158
    Mail
    nikyo@kumamoto-u.ac.jp
Copyright 2019 KUMAMOTO University HRI All Rights Reserved.