KUMAMOTO University

R

研究業績RESEARCH ACHIEVEMENTS

  1. Ghosh AK, R Nyalapatla P, Kovela S, Rao KV, Brindisi M, Osswald HL, Amano M, Aoki M, Agniswamy J, Wang YF, Weber IT, Mitsuya H.

    Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis.

    J Med Chem. 2018 May 24;61(10):4561-4577. doi: 10.1021/acs.jmedchem.8b00298. Epub 2018 May 15. PMID: 29763303; PMCID: PMC6044451.

    https://pubmed.ncbi.nlm.nih.gov/29763303/

  2. Takagi S, Tsukamoto S, Park J, Johnson KE, Kawano Y, Moschetta M, Liu CJ, Mishima Y, Kokubun K, Manier S, Salem KZ, Huynh D, Sacco A, Forward J, Roccaro AM, Battinelli EM, Ghobrial IM.

    Platelets Enhance Multiple Myeloma Progression via IL-1β Upregulation.

    Clin Cancer Res. 2018 May 15;24(10):2430-2439. doi: 10.1158/1078-0432.CCR-17-2003. Epub 2018 Feb 9. PMID: 29440174.

    https://pubmed.ncbi.nlm.nih.gov/29440174/

     

  3. Fujii E, Inada Y, Kakoki M, Nishimura N, Endo S, Fujiwara S, Wada N, Kawano Y, Okuno Y, Sugimoto T, Hata H.

    Bufalin induces DNA damage response under hypoxic condition in myeloma cells.

    Oncol Lett. 2018 May;15(5):6443-6449. doi: 10.3892/ol.2018.8091. Epub 2018 Feb 21. PMID: 29616114; PMCID: PMC5876453.

    https://pubmed.ncbi.nlm.nih.gov/29440174/

  4. Shichijo T, Fuji S, Tajima K, Kubo H, Nozaki K, Honda T, Yamaguchi J, Kawashima I, Kawajiri A, Takemura T, Onishi A, Ito A, Tanaka T, Inamoto Y, Kurosawa S, Kim SW, Fukuda T.

    Beneficial impact of low-dose rabbit anti-thymocyte globulin in unrelated hematopoietic stem cell transplantation: focusing on difference between stem cell sources.

    Bone Marrow Transplant. 2018 May;53(5):634-639. doi: 10.1038/s41409-017-0045-9. Epub 2018 Jan 15. PMID: 29335624.

    https://pubmed.ncbi.nlm.nih.gov/29335624/

  5. Fuji S, Utsunomiya A, Inoue Y, Miyagi T, Owatari S, Sawayama Y, Moriuchi Y, Choi I, Shindo T, Yoshida SI, Yamasaki S, Yamaguchi T, Fukuda T.

    Outcomes of patients with relapsed aggressive adult T-cell leukemia-lymphoma: clinical effectiveness of anti-CCR4 antibody and allogeneic hematopoietic stem cell transplantation.

    Haematologica. 2018 May;103(5):e211-e214. doi: 10.3324/haematol.2017.184564. Epub 2018 Jan 25. PMID: 29371324; PMCID: PMC5927966.

    https://pubmed.ncbi.nlm.nih.gov/29371324/

  6. Ishikawa J, Matsumura I, Kawaguchi T, Kuroda J, Nakamae H, Miyamoto T, Matsuoka KI, Shibayama H, Hino M, Hirase C, Kamimura T, Shimose T, Akashi K, Kanakura Y.

    Efficacy and safety of switching to nilotinib in patients with CML-CP in major molecular response to imatinib: results of a multicenter phase II trial (NILSw trial).

    Int J Hematol. 2018 May;107(5):535-540. doi: 10.1007/s12185-018-2401-y. Epub 2018 Jan 23. PMID: 29362980.

  7. Sato E, Iriyama N, Tokuhira M, Takaku T, Ishikawa M, Nakazato T, Sugimoto KJ, Fujita H, Fujioka I, Asou N, Komatsu N, Kizaki M, Hatta Y, Kawaguchi T.

    Introduction of second-generation tyrosine kinase inhibitors may reduce the prognostic impact of high-risk patients, according to the European treatment and outcome study (EUTOS) score.

    Leuk Lymphoma. 2018 May;59(5):1105-1112. doi: 10.1080/10428194.2017.1365858. Epub 2017 Aug 25. PMID: 28838287.

    https://pubmed.ncbi.nlm.nih.gov/28838287/

  8. Oda S, Nakaura T, Utsunomiya D, Nakaura T, Takashio S, Izumiya Y, Tsujita K, Ueda M,Yamashita T, Ando Y, Kawano Y, Okuno Y, Hata H, Yamashita Y.

    Role of Noninvasive Diagnostic Imaging in Cardiac Amyloidosis

    A Review Cardiovascular Imaging Asia. 2018 Apr;2(2):97-106. doi.org/10.22468/cvia.2018.00059.

  9. Tanaka A, Matsuoka M.

    HTLV-1 Alters T Cells for Viral Persistence and Transmission.

    Front Microbiol. 2018 Mar 20;9:461. doi: 10.3389/fmicb.2018.00461. PMID: 29615995; PMCID: PMC5869182.

    https://pubmed.ncbi.nlm.nih.gov/29615995/

  10. Tokunaga K, Yamamura A, Ueno S, Kikukawa Y, Yamaguchi S, Hidaka M, Matsuno N, Kawaguchi T, Matsuoka M, Okuno Y.

    Isolated Pancreatic Myeloid Sarcoma Associated with t(8;21)/RUNX1-RUNX1T1 Rearrangement.

    Intern Med. 2018 Feb 15;57(4):563-568. doi: 10.2169/internalmedicine.8912-17. Epub 2017 Nov 20. PMID: 29151502; PMCID: PMC5849554.

    https://pubmed.ncbi.nlm.nih.gov/29151502/

  11. Tokuhira M, Kimura Y, Sugimoto K, Nakazato T, Ishikawa M, Fujioka I, Takaku T, Iriyama N, Sato E, Fujita H, Hatta Y, Komatsu N, Asou N, Kizaki M, Kawaguchi T.

    Efficacy and safety of nilotinib therapy in patients with newly diagnosed chronic myeloid leukemia in the chronic phase.

    Med Oncol. 2018 Feb 13;35(3):38. doi: 10.1007/s12032-018-1093-8. PMID: 29442179.

    https://pubmed.ncbi.nlm.nih.gov/29442179/

  12. Sato T, Coler-Reilly ALG, Yagishita N, Araya N, Inoue E, Furuta R, Watanabe T, Uchimaru K, Matsuoka M, Matsumoto N, Hasegawa Y, Yamano Y.

    Mogamulizumab (Anti-CCR4) in HTLV-1-Associated Myelopathy.

    N Engl J Med. 2018 Feb 8;378(6):529-538. doi: 10.1056/NEJMoa1704827. PMID: 29414279.

    https://pubmed.ncbi.nlm.nih.gov/29414279/

  13. Mahgoub M, Yasunaga JI, Iwami S, Nakaoka S, Koizumi Y, Shimura K, Matsuoka M.

    Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells.

    Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1269-E1278. doi: 10.1073/pnas.1715724115. Epub 2018 Jan 22. PMID: 29358408; PMCID: PMC5819419.

    https://pubmed.ncbi.nlm.nih.gov/29358408/

     

  14. Kawashima I, Inamoto Y, Maeshima AM, Nomoto J, Tajima K, Honda T, Shichijo T, Kawajiri A, Takemura T, Onishi A, Ito A, Tanaka T, Fuji S, Kurosawa S, Kim SW, Maruyama D, Tobinai K, Kobayashi Y, Fukuda T.

    Double-Expressor Lymphoma Is Associated with Poor Outcomes after Allogeneic Hematopoietic Cell Transplantation.

    Biol Blood Marrow Transplant. 2018 Feb;24(2):294-300. doi: 10.1016/j.bbmt.2017.10.013. Epub 2017 Oct 14. PMID: 29037890.

    https://pubmed.ncbi.nlm.nih.gov/29037890/

     

  15. Shimazaki C, Hata H, Iida S, Ueda M, Katoh N, Sekijima Y, Ikeda S, Yazaki M, Fukushima W, Ando Y.

    Nationwide Survey of 741 Patients with Systemic Amyloid Light-chain Amyloidosis in Japan.

    Intern Med. 2018 Jan 15;57(2):181-187. doi: 10.2169/internalmedicine.9206-17. Epub 2017 Nov 1. PMID: 29093404; PMCID: PMC5820034.

    https://pubmed.ncbi.nlm.nih.gov/29093404/

     

  16. Kataoka K, Iwanaga M, Yasunaga JI, Nagata Y, Kitanaka A, Kameda T, Yoshimitsu M, Shiraishi Y, Sato-Otsubo A, Sanada M, Chiba K, Tanaka H, Ochi Y, Aoki K, Suzuki H, Shiozawa Y, Yoshizato T, Sato Y, Yoshida K, Nosaka K, Hishizawa M, Itonaga H, Imaizumi Y, Munakata W, Shide K, Kubuki Y, Hidaka T, Nakamaki T, Ishiyama K, Miyawaki S, Ishii R, Nureki O, Tobinai K, Miyazaki Y, Takaori-Kondo A, Shibata T, Miyano S, Ishitsuka K, Utsunomiya A, Shimoda K, Matsuoka M, Watanabe T, Ogawa S.

    Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma.

    Blood. 2018 Jan 11;131(2):215-225. doi: 10.1182/blood-2017-01-761874. Epub 2017 Oct 30. PMID: 29084771; PMCID: PMC5757690.

    https://pubmed.ncbi.nlm.nih.gov/29084771/

     

  17. Satoru Kohgo, Shuhei Imoto, Ryoh Tokuda, Yuki Takamatsu, Nobuyo Higashi-Kuwata, Manabu Aoki, Masayuki Amano, Hisao Kansui, Kengo Onitsuka, Kenji Maeda, Hiroaki Mitsuya.

    Synthesis of 4’‐Substituted Purine 2’‐Deoxynucleosides and Their Activity against Human Immunodeficiency Virus Type 1 and Hepatitis B Virus.

    ChemistrySelect. 2018;3(11):3313–3317. doi.org/10.1002/slct.201800527

    https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/slct.201800527

     

  18. Shichijo T, Fuji S.

    Hematopoietic stem cell transplantation for T-cell lymphoma.

    Adv Cell Gene Ther. 2018;1:e6. doi.org/10.1002/acg2.6.

  19. Komohara Y, Noyori O, Saito Y, Takeya H, Baghdadi M, Kitagawa F, Hama N, Ishikawa K, Okuno Y, Nosaka K, Seino KI, Matsuoka M, Suzu S.

    Potential anti-lymphoma effect of M-CSFR inhibitor in adult T-cell leukemia/lymphoma.

    J Clin Exp Hematop. 2018;58(4):152-160. doi: 10.3960/jslrt.18034. PMID: 30541986; PMCID: PMC6407477.

    https://pubmed.ncbi.nlm.nih.gov/30541986/

     

  20. Yasunaga JI, Matsuoka M.

    Oncogenic spiral by infectious pathogens: Cooperation of multiple factors in cancer development.

    Cancer Sci. 2018 Jan;109(1):24-32. doi: 10.1111/cas.13443. Epub 2017 Dec 3. PMID: 29143406; PMCID: PMC5765297.

    https://pubmed.ncbi.nlm.nih.gov/29143406/

     

  21. Yasunaga JI, Matsuoka M.

    Oncogenic spiral by infectious pathogens: Cooperation of multiple factors in cancer development.

    Cancer Sci. 2018 Jan;109(1):24-32. doi: 10.1111/cas.13443. Epub 2017 Dec 3. PMID: 29143406; PMCID: PMC5765297.

    https://pubmed.ncbi.nlm.nih.gov/29143406/

     

  22. Kawaguchi T.

    [Management of paroxysmal nocturnal hemoglobinuria: an update].

    Rinsho Ketsueki. 2018;59(6):703-710. Japanese. doi: 10.11406/rinketsu.59.703. PMID: 29973448.

    https://pubmed.ncbi.nlm.nih.gov/29973448/

     

  23. Chao HW, Doi M, Fustin JM, Chen H, Murase K, Maeda Y, Hayashi H, Tanaka R, Sugawa M, Mizukuchi N, Yamaguchi Y, Yasunaga JI, Matsuoka M, Sakai M, Matsumoto M, Hamada S, Okamura H.

    Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway.

    Nat Commun. 2017 Dec 21;8(1):2238. doi: 10.1038/s41467-017-02207-7. PMID: 29269828; PMCID: PMC5740157.

    https://pubmed.ncbi.nlm.nih.gov/29269828/

     

  24. Ghosh AK, Fyvie WS, Brindisi M, Steffey M, Agniswamy J, Wang YF, Aoki M, Amano M, Weber IT, Mitsuya H.

    Design, Synthesis, Biological Evaluation, and X-ray Studies of HIV-1 Protease Inhibitors with Modified P2′ Ligands of Darunavir.

    ChemMedChem. 2017 Dec 7;12(23):1942-1952. doi: 10.1002/cmdc.201700614. Epub 2017 Nov 24. PMID: 29110408; PMCID: PMC5896574.

    https://pubmed.ncbi.nlm.nih.gov/29110408/

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