KUMAMOTO University

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研究業績RESEARCH ACHIEVEMENTS

  1. Ghosh AK, Sean Fyvie W, Brindisi M, Steffey M, Agniswamy J, Wang YF, Aoki M, Amano M, Weber IT, Mitsuya H.

    Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1′-P2′ ligands.

    Bioorg Med Chem Lett. 2017 Nov 1;27(21):4925-4931. doi: 10.1016/j.bmcl.2017.09.003. Epub 2017 Sep 6. PMID: 28958624; PMCID: PMC5647257.

  2. Ghosh AK, Fyvie WS, Brindisi M, Steffey M, Agniswamy J, Wang YF, Aoki M, Amano M, Weber IT, Mitsuya H.

    Design, Synthesis, Biological Evaluation, and X-ray Studies of HIV-1 Protease Inhibitors with Modified P2′ Ligands of Darunavir.

    ChemMedChem. 2017 Dec 7;12(23):1942-1952. doi: 10.1002/cmdc.201700614. Epub 2017 Nov 24. PMID: 29110408; PMCID: PMC5896574.

  3. Bangham CRM, Matsuoka M.

    Human T-cell leukaemia virus type 1: parasitism and pathogenesis.

    Philos Trans R Soc Lond B Biol Sci. 2017 Oct 19;372(1732):20160272. doi: 10.1098/rstb.2016.0272. PMID: 28893939; PMCID: PMC5597739.

  4. Yasunaga JI, Matsuoka M.

    Oncogenic spiral by infectious pathogens: Cooperation of multiple factors in cancer development.

    Cancer Sci. 2018 Jan;109(1):24-32. doi: 10.1111/cas.13443. Epub 2017 Dec 3. PMID: 29143406; PMCID: PMC5765297.

  5. Takiuchi Y, Kobayashi M, Tada K, Iwai F, Sakurada M, Hirabayashi S, Nagata K, Shirakawa K, Shindo K, Yasunaga JI, Murakawa Y, Rajapakse V, Pommier Y, Matsuoka M, Takaori-Kondo A.

    HTLV-1 bZIP factor suppresses TDP1 expression through inhibition of NRF-1 in adult T-cell leukemia.

    Sci Rep. 2017 Oct 9;7(1):12849. doi: 10.1038/s41598-017-12924-0. PMID: 28993637; PMCID: PMC5634466.

  6. Kataoka K, Iwanaga M, Yasunaga JI, Nagata Y, Kitanaka A, Kameda T, Yoshimitsu M, Shiraishi Y, Sato-Otsubo A, Sanada M, Chiba K, Tanaka H, Ochi Y, Aoki K, Suzuki H, Shiozawa Y, Yoshizato T, Sato Y, Yoshida K, Nosaka K, Hishizawa M, Itonaga H, Imaizumi Y, Munakata W, Shide K, Kubuki Y, Hidaka T, Nakamaki T, Ishiyama K, Miyawaki S, Ishii R, Nureki O, Tobinai K, Miyazaki Y, Takaori-Kondo A, Shibata T, Miyano S, Ishitsuka K, Utsunomiya A, Shimoda K, Matsuoka M, Watanabe T, Ogawa S.

    Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma.

    Blood. 2018 Jan 11;131(2):215-225. doi: 10.1182/blood-2017-01-761874. Epub 2017 Oct 30. PMID: 29084771; PMCID: PMC5757690.

  7. Chao HW, Doi M, Fustin JM, Chen H, Murase K, Maeda Y, Hayashi H, Tanaka R, Sugawa M, Mizukuchi N, Yamaguchi Y, Yasunaga JI, Matsuoka M, Sakai M, Matsumoto M, Hamada S, Okamura H.

    Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway.

    Nat Commun. 2017 Dec 21;8(1):2238. doi: 10.1038/s41467-017-02207-7. PMID: 29269828; PMCID: PMC5740157.

  8. Sato T, Coler-Reilly ALG, Yagishita N, Araya N, Inoue E, Furuta R, Watanabe T, Uchimaru K, Matsuoka M, Matsumoto N, Hasegawa Y, Yamano Y.

    Mogamulizumab (Anti-CCR4) in HTLV-1-Associated Myelopathy.

    N Engl J Med. 2018 Feb 8;378(6):529-538. doi: 10.1056/NEJMoa1704827. PMID: 29414279.

  9. Furuta R, Yasunaga JI, Miura M, Sugata K, Saito A, Akari H, Ueno T, Takenouchi N, Fujisawa JI, Koh KR, Higuchi Y, Mahgoub M, Shimizu M, Matsuda F, Melamed A, Bangham CR, Matsuoka M.

    Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo.

    PLoS Pathog. 2017 Nov 29;13(11):e1006722. doi: 10.1371/journal.ppat.1006722. PMID: 29186194; PMCID: PMC5724899.

  10. Mahgoub M, Yasunaga JI, Iwami S, Nakaoka S, Koizumi Y, Shimura K, Matsuoka M.

    Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells.

    Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1269-E1278. doi: 10.1073/pnas.1715724115. Epub 2018 Jan 22. PMID: 29358408; PMCID: PMC5819419.

  11. Yasuma K, Matsuzaki T, Yamano Y, Takashima H, Matsuoka M, Saito M.

    HTLV-1 subgroups associated with the risk of HAM/TSP are related to viral and host gene expression in peripheral blood mononuclear cells, independent of the transactivation functions of the viral factors.

    J Neurovirol. 2016 Aug;22(4):416-30. doi: 10.1007/s13365-015-0407-2. Epub 2015 Dec 3. PMID: 26635027.

  12. Kawatsuki A, Yasunaga JI, Mitobe Y, Green PL, Matsuoka M.

    HTLV-1 bZIP factor protein targets the Rb/E2F-1 pathway to promote proliferation and apoptosis of primary CD4(+) T cells.

    Oncogene. 2016 Aug 25;35(34):4509-17. doi: 10.1038/onc.2015.510. Epub 2016 Jan 25. PMID: 26804169; PMCID: PMC4959989.

  13. Doi M, Murai I, Kunisue S, Setsu G, Uchio N, Tanaka R, Kobayashi S, Shimatani H, Hayashi H, Chao HW, Nakagawa Y, Takahashi Y, Hotta Y, Yasunaga J, Matsuoka M, Hastings MH, Kiyonari H, Okamura H.

    Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour.

    Nat Commun. 2016 Feb 17;7:10583. doi: 10.1038/ncomms10583. PMID: 26882873; PMCID: PMC4757782.

  14. Kuribayashi W, Takizawa K, Sugata K, Kuramitsu M, Momose H, Sasaki E, Hiradate Y, Furuhata K, Asada Y, Iwama A, Matsuoka M, Mizukami T, Hamaguchi I.

    Impact of the SCF signaling pathway on leukemia stem cell-mediated ATL initiation and progression in an HBZ transgenic mouse model.

    Oncotarget. 2016 Aug 9;7(32):51027-51043. doi: 10.18632/oncotarget.10210. PMID: 27340921; PMCID: PMC5239456.

  15. Sugata K, Yasunaga J, Miura M, Akari H, Utsunomiya A, Nosaka K, Watanabe Y, Suzushima H, Koh KR, Nakagawa M, Kohara M, Matsuoka M.

    Enhancement of anti-STLV-1/HTLV-1 immune responses through multimodal effects of anti-CCR4 antibody.

    Sci Rep. 2016 Jun 2;6:27150. doi: 10.1038/srep27150. PMID: 27250643; PMCID: PMC4890010.

  16. Alam M, Kuwata T, Shimura K, Yokoyama M, Ramirez Valdez KP, Tanaka K, Maruta Y, Oishi S, Fujii N, Sato H, Matsuoka M, Matsushita S.

    Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors.

    Retrovirology. 2016 Sep 27;13(1):70. doi: 10.1186/s12977-016-0304-7. PMID: 27670680; PMCID: PMC5037607.

  17. Kikukawa Y, Hata H, Ueda M, Yamashita T, Nasu S, Ide K, Ueno S, Ando Y, Mitsuya H, Okuno Y.

    Successful Treatment of Amyloid Light-chain Amyloidosis in a Charcot-Marie-Tooth Disease Patient with Lenalidomide, Cyclophosphamide, and Dexamethasone.

    Intern Med. 2016;55(18):2707-12. doi: 10.2169/internalmedicine.55.5815. Epub 2016 Sep 15. PMID: 27629972.

  18. Fujiwara S, Mochinaga H, Nakata H, Ohshima K, Matsumoto M, Uchiba M, Mikami Y, Hata H, Okuno Y, Mitsuya H, Nosaka K.

    Successful treatment of TAFRO syndrome, a variant type of multicentric Castleman disease with thrombotic microangiopathy, with anti-IL-6 receptor antibody and steroids.

    Int J Hematol. 2016 Jun;103(6):718-23. doi: 10.1007/s12185-016-1978-2. Epub 2016 Mar 15. PMID: 26980221.

  19. Higuchi Y, Tokunaga K, Watanabe Y, Kawakita T, Harada N, Yamaguchi S, Nosaka K, Mitsuya H, Asou N.

    Lineage switch with t(6;11)(q27;q23) from T-cell lymphoblastic lymphoma to acute monoblastic leukemia at relapse.

    Cancer Genet. 2016 Jun;209(6):267-71. doi: 10.1016/j.cancergen.2016.05.070. Epub 2016 May 18. PMID: 27268298.

  20. Ghosh AK, Osswald HL, Glauninger K, Agniswamy J, Wang YF, Hayashi H, Aoki M, Weber IT, Mitsuya H. Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV-1 Protease Inhibitors: Design, Synthesis, Protein X-ray Structural Studies, and Biological Evaluation. J Med Chem. 2016 Jul 28;59(14):6826-37. doi: 10.1021/acs.jmedchem.6b00639. Epub 2016 Jul 7. PMID: 27389367; PMCID: PMC5360270.

  21. Kumamoto H, Fukano M, Nakano T, Iwagami K, Takeyama C, Kohgo S, Imoto S, Amano M, Kuwata-Higashi N, Aoki M, Abe H, Mitsuya H, Fukuhara K, Haraguchi K.

    Diastereoselective Synthesis of 6″-(Z)- and 6″-(E)-Fluoro Analogues of Anti-hepatitis B Virus Agent Entecavir and Its Evaluation of the Activity and Toxicity Profile of the Diastereomers.

    J Org Chem. 2016 Apr 1;81(7):2827-36. doi: 10.1021/acs.joc.6b00105. Epub 2016 Mar 24. PMID: 27009432.

  22. Endo S, Amano M, Nishimura N, Ueno N, Ueno S, Yuki H, Fujiwara S, Wada N, Hirata S, Hata H, Mitsuya H, Okuno Y.

    Immunomodulatory drugs act as inhibitors of DNA methyltransferases and induce PU.1 up-regulation in myeloma cells.

    Biochem Biophys Res Commun. 2016 Jan 8;469(2):236-42. doi: 10.1016/j.bbrc.2015.11.116. Epub 2015 Nov 30. PMID: 26657848.

  23. Nakamura T, Campbell JR, Moore AR, Otsu S, Aikawa H, Tamamura H, Mitsuya H.

    Development and validation of a cell-based assay system to assess human immunodeficiency virus type 1 integrase multimerization.

    J Virol Methods. 2016 Oct;236:196-206. doi: 10.1016/j.jviromet.2016.07.023. Epub 2016 Jul 26. PMID: 27474494.

  24. Salie ZL, Kirby KA, Michailidis E, Marchand B, Singh K, Rohan LC, Kodama EN, Mitsuya H, Parniak MA, Sarafianos SG.

    Structural basis of HIV inhibition by translocation-defective RT inhibitor 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA).

    Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9274-9. doi: 10.1073/pnas.1605223113. Epub 2016 Aug 3. PMID: 27489345; PMCID: PMC4995989.

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