KUMAMOTO University

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研究業績RESEARCH ACHIEVEMENTS

  1. Ghosh AK, Fyvie WS, Brindisi M, Steffey M, Agniswamy J, Wang YF, Aoki M, Amano M, Weber IT, Mitsuya H.

    Design, Synthesis, Biological Evaluation, and X-ray Studies of HIV-1 Protease Inhibitors with Modified P2′ Ligands of Darunavir.

    ChemMedChem. 2017 Dec 7;12(23):1942-1952. doi: 10.1002/cmdc.201700614. Epub 2017 Nov 24. PMID: 29110408; PMCID: PMC5896574.

    https://pubmed.ncbi.nlm.nih.gov/29110408/

  2. Furuta R, Yasunaga JI, Miura M, Sugata K, Saito A, Akari H, Ueno T, Takenouchi N, Fujisawa JI, Koh KR, Higuchi Y, Mahgoub M, Shimizu M, Matsuda F, Melamed A, Bangham CR, Matsuoka M.

    Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo.

    PLoS Pathog. 2017 Nov 29;13(11):e1006722. doi: 10.1371/journal.ppat.1006722. PMID: 29186194; PMCID: PMC5724899.

    https://pubmed.ncbi.nlm.nih.gov/29186194/

  3. Ghosh AK, Sean Fyvie W, Brindisi M, Steffey M, Agniswamy J, Wang YF, Aoki M, Amano M, Weber IT, Mitsuya H.

    Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1′-P2′ ligands.

    Bioorg Med Chem Lett. 2017 Nov 1;27(21):4925-4931. doi: 10.1016/j.bmcl.2017.09.003. Epub 2017 Sep 6. PMID: 28958624; PMCID: PMC5647257.

    https://pubmed.ncbi.nlm.nih.gov/28958624/

     

  4. Bangham CRM, Matsuoka M.

    Human T-cell leukaemia virus type 1: parasitism and pathogenesis.

    Philos Trans R Soc Lond B Biol Sci. 2017 Oct 19;372(1732):20160272. doi: 10.1098/rstb.2016.0272. PMID: 28893939; PMCID: PMC5597739.

    https://pubmed.ncbi.nlm.nih.gov/28893939/

  5. Takiuchi Y, Kobayashi M, Tada K, Iwai F, Sakurada M, Hirabayashi S, Nagata K, Shirakawa K, Shindo K, Yasunaga JI, Murakawa Y, Rajapakse V, Pommier Y, Matsuoka M, Takaori-Kondo A.

    HTLV-1 bZIP factor suppresses TDP1 expression through inhibition of NRF-1 in adult T-cell leukemia.

    Sci Rep. 2017 Oct 9;7(1):12849. doi: 10.1038/s41598-017-12924-0. PMID: 28993637; PMCID: PMC5634466.

    https://pubmed.ncbi.nlm.nih.gov/28993637/

  6. Ghosh AK, Brindisi M, Nyalapatla PR, Takayama J, Ella-Menye JR, Yashchuk S, Agniswamy J, Wang YF, Aoki M, Amano M, Weber IT, Mitsuya H.

    Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex.

    Bioorg Med Chem. 2017 Oct 1;25(19):5114-5127. doi: 10.1016/j.bmc.2017.04.005. Epub 2017 Apr 9. PMID: 28434781; PMCID: PMC5617771.

    https://pubmed.ncbi.nlm.nih.gov/28434781/

  7. Amano M, Miguel Salcedo-Gómez P, Yedidi RS, Delino NS, Nakata H, Venkateswara Rao K, Ghosh AK, Mitsuya H.

    GRL-09510, a Unique P2-Crown-Tetrahydrofuranylurethane -Containing HIV-1 Protease Inhibitor, Maintains Its Favorable Antiviral Activity against Highly-Drug-Resistant HIV-1 Variants in vitro.

    Sci Rep. 2017 Sep 25;7(1):12235. doi: 10.1038/s41598-017-12052-9. PMID: 28947797; PMCID: PMC5613016.

    https://pubmed.ncbi.nlm.nih.gov/28947797/

  8. Ueno N, Nishimura N, Ueno S, Endo S, Tatetsu H, Hirata S, Hata H, Matsuoka M, Mitsuya H, Okuno Y.

    PU.1 acts as tumor suppressor for myeloma cells through direct transcriptional repression of IRF4.

    Oncogene. 2017 Aug;36(31):4481-4497. doi: 10.1038/onc.2017.79. Epub 2017 Apr 3. PMID: 28368411.

    https://pubmed.ncbi.nlm.nih.gov/28368411/

  9. Kawajiri A, Fuji S, Tanaka Y, Kono C, Hirakawa T, Tanaka T, Ito R, Inoue Y, Okinaka K, Kurosawa S, Inamoto Y, Kim SW, Yamashita T, Fukuda T.

    Clinical impact of hyperglycemia on days 0-7 after allogeneic stem cell transplantation.

    Bone Marrow Transplant. 2017 Aug;52(8):1156-1163. doi: 10.1038/bmt.2017.27. Epub 2017 Mar 20. PMID: 28319076.

    https://pubmed.ncbi.nlm.nih.gov/28319076/

  10. Kumamoto H, Fukano M, Imoto S, Kohgo S, Odanaka Y, Amano M, Kuwata-Higashi N, Mitsuya H, Haraguchi K, Fukuhara K.

    A novel entecavir analogue constructing with a spiro[2.4]heptane core structure in the aglycon moiety: Its synthesis and evaluation for anti-hepatitis B virus activity.

    Nucleosides Nucleotides Nucleic Acids. 2017 Jul 3;36(7):463-473. doi: 10.1080/15257770.2017.1322209. Epub 2017 Jun 2. PMID: 28574799.

    https://pubmed.ncbi.nlm.nih.gov/28574799/

  11. Fuji S, Yamaguchi T, Inoue Y, Utsunomiya A, Moriuchi Y, Uchimaru K, Owatari S, Miyagi T, Taguchi J, Choi I, Otsuka E, Nakachi S, Yamamoto H, Kurosawa S, Tobinai K, Fukuda T.

    Development of a modified prognostic index for patients with aggressive adult T-cell leukemia-lymphoma aged 70 years or younger: possible risk-adapted management strategies including allogeneic transplantation.

    Haematologica. 2017 Jul;102(7):1258-1265. doi: 10.3324/haematol.2017.164996. Epub 2017 Mar 24. PMID: 28341734; PMCID: PMC5566038.

    https://pubmed.ncbi.nlm.nih.gov/28341734/

  12. Nishimura N, Endo S, Ueno S, Ueno N, Tatetsu H, Hirata S, Hata H, Komohara Y, Takeya M, Mitsuya H, Okuno Y.

    A xenograft model reveals that PU.1 functions as a tumor suppressor for multiple myeloma in vivo.

    Biochem Biophys Res Commun. 2017 May 13;486(4):916-922. doi: 10.1016/j.bbrc.2017.03.124. Epub 2017 Mar 24. PMID: 28347818.

    https://pubmed.ncbi.nlm.nih.gov/28347818/

  13. Tanaka Y, Kurosawa S, Tajima K, Tanaka T, Ito R, Inoue Y, Okinaka K, Inamoto Y, Fuji S, Kim SW, Tanosaki R, Yamashita T, Fukuda T.

    Increased incidence of oral and gastrointestinal secondary cancer after allogeneic hematopoietic stem cell transplantation.

    Bone Marrow Transplant. 2017 May;52(5):789-791. doi: 10.1038/bmt.2017.4. Epub 2017 Feb 13. PMID: 28194030.

    https://pubmed.ncbi.nlm.nih.gov/28194030/

  14. Makita S, Munakata W, Watabe D, Maeshima AM, Taniguchi H, Toyoda K, Yamauchi N, Fukuhara S, Maruyama D, Kobayashi Y, Tobinai K.

    Azacitidine-induced acute lung injury in a patient with therapy-related myelodysplastic syndrome.

    J Int Med Res. 2017 Apr;45(2):886-893. doi: 10.1177/0300060517698331. Epub 2017 Mar 16. PMID: 28415946; PMCID: PMC5536648.

    https://pubmed.ncbi.nlm.nih.gov/28415946/

  15. Kinosada H, Yasunaga JI, Shimura K, Miyazato P, Onishi C, Iyoda T, Inaba K, Matsuoka M.

    HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors.

    PLoS Pathog. 2017 Jan 3;13(1):e1006120. doi: 10.1371/journal.ppat.1006120. Erratum in: PLoS Pathog. 2017 Feb 23;13(2):e1006228. PMID: 28046066; PMCID: PMC5234849.

    https://pubmed.ncbi.nlm.nih.gov/28046066/

  16. Kawano Y, Roccaro AM, Ghobrial IM, Azzi J.

    Multiple Myeloma and the Immune Microenvironment.

    Curr Cancer Drug Targets. 2017;17(9):806-818. doi: 10.2174/1568009617666170214102301. PMID: 28201978.

    https://pubmed.ncbi.nlm.nih.gov/28201978/

  17. Amano M, Salcedo-Gómez PM, Zhao R, Yedidi RS, Das D, Bulut H, Delino NS, Sheri VR, Ghosh AK, Mitsuya H.

    A Modified P1 Moiety Enhances In Vitro Antiviral Activity against Various Multidrug-Resistant HIV-1 Variants and In Vitro Central Nervous System Penetration Properties of a Novel Nonpeptidic Protease Inhibitor, GRL-10413.

    Antimicrob Agents Chemother. 2016 Nov 21;60(12):7046-7059. doi: 10.1128/AAC.01428-16. PMID: 27620483; PMCID: PMC5118983.

    https://pubmed.ncbi.nlm.nih.gov/27620483/

  18. Nakamura T, Campbell JR, Moore AR, Otsu S, Aikawa H, Tamamura H, Mitsuya H.

    Development and validation of a cell-based assay system to assess human immunodeficiency virus type 1 integrase multimerization.

    J Virol Methods. 2016 Oct;236:196-206. doi: 10.1016/j.jviromet.2016.07.023. Epub 2016 Jul 26. PMID: 27474494.

    https://pubmed.ncbi.nlm.nih.gov/27474494/

  19. Fuji S, Inoue Y, Utsunomiya A, Moriuchi Y, Uchimaru K, Choi I, Otsuka E, Henzan H, Kato K, Tomoyose T, Yamamoto H, Kurosawa S, Matsuoka K, Yamaguchi T, Fukuda T.

    Pretransplantation Anti-CCR4 Antibody Mogamulizumab Against Adult T-Cell Leukemia/Lymphoma Is Associated With Significantly Increased Risks of Severe and Corticosteroid-Refractory Graft-Versus-Host Disease, Nonrelapse Mortality, and Overall Mortality.

    J Clin Oncol. 2016 Oct 1;34(28):3426-33. doi: 10.1200/JCO.2016.67.8250. Epub 2016 Aug 9. PMID: 27507878.

    https://pubmed.ncbi.nlm.nih.gov/27507878/

  20. Alam M, Kuwata T, Shimura K, Yokoyama M, Ramirez Valdez KP, Tanaka K, Maruta Y, Oishi S, Fujii N, Sato H, Matsuoka M, Matsushita S.

    Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors.

    Retrovirology. 2016 Sep 27;13(1):70. doi: 10.1186/s12977-016-0304-7. PMID: 27670680; PMCID: PMC5037607.

    https://pubmed.ncbi.nlm.nih.gov/27670680/

  21. Sugata K, Yasunaga J, Kinosada H, Mitobe Y, Furuta R, Mahgoub M, Onishi C, Nakashima K, Ohshima K, Matsuoka M.

    HTLV-1 Viral Factor HBZ Induces CCR4 to Promote T-cell Migration and Proliferation.

    Cancer Res. 2016 Sep 1;76(17):5068-79. doi: 10.1158/0008-5472.CAN-16-0361. Epub 2016 Jul 11. PMID: 27402079.

    https://pubmed.ncbi.nlm.nih.gov/27670680/

  22. Maeshima AM, Taniguchi H, Toyoda K, Yamauchi N, Makita S, Fukuhara S, Munakata W, Maruyama D, Kobayashi Y, Tobinai K.

    Clinicopathological features of histological transformation from extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue to diffuse large B-cell lymphoma: an analysis of 467 patients.

    Br J Haematol. 2016 Sep;174(6):923-31. doi: 10.1111/bjh.14153. Epub 2016 Jul 27. PMID: 27460179.

  23. Kawatsuki A, Yasunaga JI, Mitobe Y, Green PL, Matsuoka M.

    HTLV-1 bZIP factor protein targets the Rb/E2F-1 pathway to promote proliferation and apoptosis of primary CD4(+) T cells.

    Oncogene. 2016 Aug 25;35(34):4509-17. doi: 10.1038/onc.2015.510. Epub 2016 Jan 25. PMID: 26804169; PMCID: PMC4959989.

    https://pubmed.ncbi.nlm.nih.gov/26804169/

  24. Salie ZL, Kirby KA, Michailidis E, Marchand B, Singh K, Rohan LC, Kodama EN, Mitsuya H, Parniak MA, Sarafianos SG.

    Structural basis of HIV inhibition by translocation-defective RT inhibitor 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA).

    Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9274-9. doi: 10.1073/pnas.1605223113. Epub 2016 Aug 3. PMID: 27489345; PMCID: PMC4995989.

    https://pubmed.ncbi.nlm.nih.gov/27489345/

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