世界最先端の研究で医学の発展に寄与

2017年

2017年 業績・論文

 

Arun K. Ghosh, W. Sean Fyvie, Margherita Brindisi, Melinda Steffey, Johnson Agniswamy, Yuan-Fang Wang, Manabu Aoki, Masayuki Amano, Irene T. Weber, and Hiroaki Mitsuya.

Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands.

Bioorganic & Medicinal Chemistry Letters. In press.

 

Masayuki Amano, Pedro Miguel Salcedo-Gómez, Ravikiran S. Yedidi, Nicole S. Delino, Hirotomo Nakata, Kalapala Venkateswara Rao, Arun K. Ghosh, Hiroaki Mitsuya.

GRL-09510, a Unique P2-Crown-Tetrahydrofuranylurethane -Containing HIV-1 Protease Inhibitor, Maintains Its Favorable Antiviral Activity against Highly-Drug-Resistant HIV-1 Variants in vitro.

Scientific Reports. 7: 12235, 2017.

 

Hiroki Kumamoto, Misato Fukano, Shuhei Imoto, Satoru Kohgo, Yuki Odanaka, Masayuki Amano, Nobuyo Kuwata-Higashi, Hiroaki Mitsuya, Kazuhiro Haraguchi, Kiyoshi Fukuhara.

A novel entecavir analogue constructing with a spiro[2.4]heptane core structure in the aglycon moiety: Its synthesis and evaluation for antihepatitis B virus activity.

Nucleosides, Nucleotides and Nucleic Acids. 36(7):463-473, 2017.

 

Arun K. Ghosh, Margherita Brindisi, Prasanth R. Nyalapatla, Jun Takayama, Jean-Rene Ella-Menye, Sofiya Yashchuk, Johnson Agniswamy, Yuan-Fang Wang, Manabu Aoki, Masayuki Amano, Irene T. Weber, Hiroaki Mitsuya.

Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex.

Bioorganic & Medicinal Chemistry, 25(19):5114-5127, 2017.

 

Kawajiri A, Fuji S, Tanaka Y, Kono C, Hirakawa T, Tanaka T, Ito R, Inoue Y, Okinaka K, Kurosawa S, Inamoto Y, Kim SW, Yamashita T, Fukuda T. 

Clinical impact of hyperglycemia on days 0-7 after allogeneic stem cell transplantation. 

Bone Marrow Transplant. In press. 2017. 

 

Tanaka Y, Kurosawa S, Tajima K, Tanaka T, Ito R, Inoue Y, Okinaka K, Inamoto Y, Fuji S, Kim SW, Tanosaki R, Yamashita T, Fukuda T.

Increased incidence of oral and gastrointestinal secondary cancer after allogeneic hematopoietic stem cell transplantation.

Bone Marrow Transplant. In press. 2017.

 

Kawano Y, Roccaro AM., Azzi J, Ghobrial IM.

Multiple Myeloma and the immune microenvironment.

Current Cancer Drug Targets. In press. 2017.

 

Shigeo Fuji, Takuhiro Yamaguchi, Yoshitaka Inoue, Atae Utsunomiya, Yukiyoshi Moriuchi, Kaoru Uchimaru, Satsuki Owatari,Takashi Miyagi, Jun Taguchi, Ilseung Choi, Eiichi Otsuka, Sawako Nakachi, Hisashi Yamamoto, Saiko Kurosawa,Kensei Tobinai, Takahiro Fukuda.

Development of a modified prognostic index of patients with aggressive adult T-cell leukemia-lymphoma aged 70 years or younger: a possible risk-adapted management strategies including allogeneic transplantation.

Haematologica. In press. 2017.

 

Makita S, Munakata W, Watabe D, Maeshima AM, Taniguchi H, Toyoda K, Yamauchi N, Fukuhara S, Maruyama D, Kobayashi Y, Tobinai K.

Azacitidine-induced acute lung injury in a patient with therapy-related myelodysplastic syndrome.

J Int Med Res. 45(2):886-893. 2017.

 

Ueno N,  Nishimura N,  Ueno S,  Endo S,  Tatetsu H,  Hirata S,  Hata H,  Matsuoka M,  Mitsuya H,  Okuno Y.

PU.1 acts as tumor suppressor for myeloma cells through direct transcriptional repression of IRF4.

Oncogene. In press. 2017.

 

Nishimura N,  Endo S,  Ueno S,  Ueno N,  Tatetsu H,  Hirata S,  Hata H,  Komohara Y, Takeya M, Mitsuya H, Okuno Y.

A xenograft model reveals that PU.1 functions as a tumor suppressor for multiple myeloma in vivo.

Biochem Biophys Res Commun. 13;486(4):916-922. 2017.

 

Kinosada H, Yasunaga JI, Shimura K, Miyazato P, Onishi C, Iyoda T, Inaba K, Matsuoka M.

HTLV-1 bZIP factor enhances T-cell proliferation by impeding the suppressive signaling of co-inhibitory receptors.

PLoS Pathog.13: e1006120 2017.

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