世界最先端の研究で医学の発展に寄与

2016年

2016年 業績・論文

 

Sugata K, Yasunaga JI, Kinosada H, Mitobe Y, Furuta R, Mahgoub M, Onishi C, Nakashima K, Ohshima K, Matsuoka M.

HTLV-1 viral factor HBZ induces CCR4 to promote T cell migration and proliferation.

Cancer Res. 76: 5068-5079. 2016.

 

Yasuma K, Yasunaga JI, Takemoto K, Sugata K, Mitobe Y, Takenouchi N, Nakagawa M, Suzuki Y, Matsuoka M.

HTLV-1 bZIP factor impairs anti-viral immunity by inducing co-inhibitory molecule, T cell immunoglobulin and ITIM domain (TIGIT).

PLoS Pathog. 12: e1005372. 2016. 

 

Amano M, Salcedo-Gómez PM, Zhao R, Yedidi RS, Das D, Bulut H, Delino NS, Reddy SV, Ghosh AK, Mitsuya H.

A Modified P1 Moiety Enhances in vitro Antiviral Activity against Various Multi-Drug-Resistant HIV-1 Variants and in vitro CNS Penetration Properties of a Novel Nonpeptidic Protease Inhibitor, GRL-10413.

Antimicrob Agents Chemother. 60(12):7046-7059. 2016 Nov 21.

 

Salie ZL, Kirby KA, Michailidis E, Marchand B, Singh K, Rohan LC, Kodama EN, Mitsuya H, Parniak MA, Sarafianos SG.

Structural basis of HIV inhibition by translocation defective RT inhibitor, 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA).

Proc Natl Acad Sci U S A. 113(33):9274-9. 2016.

 

Nakamura T, Campbell JR, Moore AR, Otsu S, Aikawa H, Tamamura H, Mitsuya H.

Development and validation of a cell-based assay system to assess human immunodeficiency virus type 1 integrase multimerization.

J Virol Methods. 236:196-206. 2016.

 

Endo S, Amano M, Nishimura N, Ueno N, Ueno S, Yuki H, Fujiwara S, Wada N, Hirata S, Hata H, Mitsuya H, Okuno Y.

Immunomodulatory drugs act as inhibitors of DNA methyltransferases and induce PU.1 up-regulation in myeloma cells.

Biochem Biophys Res Commun. 469(2):236-42. 2016.

 

Kumamoto H, Fukano M, Nakano T, Iwagami K, Takeyama C, Kohgo S, Imoto S, Amano M, Kuwata-Higashi N, Aoki M, Abe H, Mitsuya H, Fukuhara K, Haraguchi K.

Diastereoselective Synthesis of 6″-(Z)- and 6″-(E)-Fluoro Analogues of Anti-hepatitis B Virus Agent Entecavir and Its Evaluation of the Activity and Toxicity Profile of the Diastereomers.

J Org Chem. 81(7):2827-36. 2016.

 

Ghosh AK, Osswald HL, Glauninger K, Agniswamy J, Wang YF, Hayashi H, Aoki M, Weber IT, Mitsuya H.

Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV-1 Protease Inhibitors: Design, Synthesis, Protein X-ray Structural Studies, and Biological Evaluation.

J Med Chem. 59: 6826-37. 2016.

 

Higuchi Y, Tokunaga K, Watanabe Y, Kawakita T, Harada N, Yamaguchi S, Nosaka K, Mitsuya H, Asou N.

Lineage switch with t(6;11)(q27;q23) from T-cell lymphoblastic lymphoma to acute monoblastic leukemia at relapse.

Cancer Genet. 209(6):267-71. 2016.

 

Fujiwara S, Mochinaga H, Nakata H, Ohshima K, Matsumoto M, Uchiba M, Mikami Y, Hata H, Okuno Y, Mitsuya H, Nosaka K.

Successful treatment of TAFRO syndrome, a variant type of multicentric Castleman disease with thrombotic microangiopathy with anti-IL-6 receptor antibody and steroids.

Int J Hematol. 103(6):718-23. 2016.

 

Kikukawa Y, Hata H, Ueda M, Yamashita T, Nasu S, Ide K, Ueno S, Ando Y, Mitsuya H, Okuno Y.

Successful Treatment of Amyloid Light-chain Amyloidosis in a Charcot-Marie-Tooth Disease Patient with Lenalidomide, Cyclophosphamide, and Dexamethasone.

Intern Med. 55(18):2707-12. 2016.

 

Alam M, Kuwata T, Shimura K, Yokoyama M, Ramirez Valdez KP, Tanaka K, Murata Y, Oishi S, Fujii N, Sato H, Matsuoka M, Matsushita S.

Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors.

Retrovirology. 13: 70. 2016.

 

Sugata K, Yasunaga JI, Miura M, Akari H, Utsunomiya A, Nosaka K, Watanabe Y, Suzushima H, Koh KR, Nakagawa M, Kohara M, Matsuoka M.

Enhancement of anti-STLV-1/HTLV-1 immune responses through multimodal effects of anti-CCR4 antibody.

Sci Rep. 6:27150. 2016.

 

Kuribayashi W, Takizawa K, Sugata K, Kuramitsu M, Momose H, Sasaki E, Furuhata K, Asada Y, Iwama A, Matsuoka M, Mizukami T, Hamaguchi I.

Impact of the SCF signaling pathway on leukemia stem cell-mediated ATL initiation and progression in an HBZ transgenic mouse model.

Oncotarget. In press. 2016.

 

Doi M, Murai I, Kunisue S, Setsu G, Uchio N, Tanaka R, Kobayashi S, Shimatani H, Hayashi H, Chao HW, Nakagawa Y, Hotta Y, Takahashi Y, Yasunaga JI, Matsuoka M, Hastings M, Kiyonari H, Okamura H.

Gpr176 is a Gz-linked orphan G-protein coupled receptor that sets the pace of circadian behavior.

Nat Commun. 7: 10583. 2016.

 

Kawatsuki A, Yasunaga J-I, Mitobe Y, Green PL, Matsuoka M.

HTLV-1 bZIP factor protein targets the Rb/E2F-1 pathway to promote proliferation and apoptosis of primary CD4+ T cells.

Oncogene. 35(34):4509-4517. 2016.

 

Yasuma K, Matsuzaki T, Yamano Y, Takashima H, Matsuoka M, Saito M.

HTLV-1 subgroups associated with the risk of HAM/TSP are related to viral and host gene expression in peripheral blood mononuclear cells, independent of the transactivation functions of the viral factors.

J Neurovirol. 22: 416-430. 2016.

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