世界最先端の研究で医学の発展に寄与

2016年

2016年 業績・論文

 

Fuji S, Inoue Y, Utsunomiya A, Moriuchi Y, Uchimaru K, Choi I, Otsuka E, Henzan H, Kato K, Tomoyose T, Yamamoto H, Kurosawa S, Matsuoka K, Yamaguchi T, Fukuda T. 

Pretransplantation Anti-CCR4 Antibody Mogamulizumab Against Adult T-Cell Leukemia/Lymphoma Is Associated With Significantly Increased Risks of Severe and Corticosteroid-Refractory Graft-Versus-Host Disease, Nonrelapse Mortality, and Overall Mortality. 

J Clin Oncol. 34(28):3426-33. 2016.

 

Makita S, Fuji S, Takano K, Tanaka T, Inoue Y, Ito R, Ito A, Hayashi Y, Tajima K, Okinaka K, Kurosawa S, Kim SW, Yamashita T, Tanosaki R, Tobinai K, Fukuda T. Clinical Outcomes after Allogeneic Stem Cell Transplantation for Adult Lymphoblastic Lymphoma. 

Journal of clinical and experimental hematopathology. 56(1):28-33. 2016.

 

Kuriyama K, Fuji S, Inamoto Y, Tajima K, Tanaka T, Inoue Y, Ito R, Hayashi Y, Ito A, Kurosawa S, Kim SW, Yamashita T, Fukuda T.

Impact of low-dose rabbit anti-thymocyte globulin in unrelated hematopoietic stem cell transplantation.

Int J Hematol. 103(4):453-60. 2016.

 

Fuji S, Fujiwara H, Nakano N, Wake A, Inoue Y, Fukuda T, Hidaka M, Moriuchi Y, Miyamoto T, Uike N, Taguchi J, Eto T, Tomoyose T, Kondo T, Yamanoha A, Ichinohe T, Atsuta Y, Utsunomiya A, Transplantation ATLWGotJSfHC. 

Early application of related SCT might improve clinical outcome in adult T-cell leukemia/lymphoma. 

Bone Marrow Transplant. 51(2):205-11. 2016.

 

Tanaka Y, Kurosawa S, Tajima K, Tanaka T, Ito R, Inoue Y, Okinaka K, Inamoto Y, Fuji S, Kim SW, Tanosaki R, Yamashita T, Fukuda T.

Analysis of non-relapse mortality and causes of death over 15 years following allogeneic hematopoietic stem cell transplantation.

Bone Marrow Transplant. 51(4):553-9. 2016.

 

Inoue Y, Fuji S, Tanosaki R, Fukuda T.

Pretransplant mogamulizumab against ATLL might increase the risk of acute GVHD and non-relapse mortality.

Bone Marrow Transplant. 51(5):725-7. 2016.

 

Moschetta M, Kawano Y, Podar K.

Targeting the Bone Marrow Microenvironment.

Cancer Treatment and Research. 169: 63-102. 2016.

 

Glavey SV, Manier S, Sacco A, Salem K, Kawano Y, Bouyssou J, Ghobrial IM, Roccaro AM.

Epigenetics in Multiple Myeloma.

Cancer Treatment and Research.169: 35-49. 2016.

 

Manier S, Kawano Y, Bianchi G, Roccro AM, Ghobrial IM.

Cell autonomous and micro-environmental regulation of tumor progression in precursor states of Multiple Myeloma.

Current Opinion in Hematology. 23 (4):426-33. 2016.

 

Roccaro AM, Sacco A, Shi J, Chiarini M, Perilla-Glen A, Manier S, Glavey S, Aljawai Y, Mishima Y, Kawano Y, Moschetta M, Correll M, Improgo MR, Brown JR, Imberti L, Rossi G, Castillo JJ, Treon S, Freedman M, Van Allen EM, Hide W, Elaine H, Rainville I, Ghobrial IM.

Exome sequencing reveals recurrent germline variants in patients with familial Waldenstrom’s Macroglobulinemia.

Blood.127 (21):2598-606. 2016.

 

Moschetta M, Mishima Y, Kawano Y, Manier S, Paiva B, Palomera L, Aljawai Y, Calcinotto A, Unitt C, Sahin I, Sacco A, Glavey S, Shi J, Reagan MR, Prosper F, Bellone M, Chesi M, Bergsagel PL, Vacca A, Roccaro AM, Ghobrial IM.

Targeting vasculogenesis to prevent progression in multiple myeloma.

Leukemia. 30 (5):1103-15. 2016.

 

Maeshima AM, Taniguchi H, Toyoda K, Yamauchi N, Makita S, Fukuhara S, Munakata W, Maruyama D, Kobayashi Y, Tobinai K.

Clinicopathological features of histological transformation from extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue to diffuse large B-cell lymphoma: an analysis of 467 patients.

Br J Haematol. 174(6):923-31. 2016.

 

Haji S, Kiyasu J, Choi I, Suehiro Y, Toyoda K, Tsuda M, Takamatsu A, Nakashima Y, Miyoshi H, Shiratsuchi M, Yamasaki S, Uike N, Abe Y.

Administration of an anti-CC chemokine receptor 4 monoclonal antibody, mogamulizumab, before allogeneic bone marrow transplantation for adult T-cell leukemia/lymphoma.

Bone Marrow Transplant. 51(3):432-4. 2015.

 

Sugata K, Yasunaga JI, Kinosada H, Mitobe Y, Furuta R, Mahgoub M, Onishi C, Nakashima K, Ohshima K, Matsuoka M.

HTLV-1 viral factor HBZ induces CCR4 to promote T cell migration and proliferation.

Cancer Res. 76: 5068-5079. 2016.

 

Yasuma K, Yasunaga JI, Takemoto K, Sugata K, Mitobe Y, Takenouchi N, Nakagawa M, Suzuki Y, Matsuoka M.

HTLV-1 bZIP factor impairs anti-viral immunity by inducing co-inhibitory molecule, T cell immunoglobulin and ITIM domain (TIGIT).

PLoS Pathog. 12: e1005372. 2016. 

 

Amano M, Salcedo-Gómez PM, Zhao R, Yedidi RS, Das D, Bulut H, Delino NS, Reddy SV, Ghosh AK, Mitsuya H.

A Modified P1 Moiety Enhances in vitro Antiviral Activity against Various Multi-Drug-Resistant HIV-1 Variants and in vitro CNS Penetration Properties of a Novel Nonpeptidic Protease Inhibitor, GRL-10413.

Antimicrob Agents Chemother. 60(12):7046-7059. 2016.

 

Salie ZL, Kirby KA, Michailidis E, Marchand B, Singh K, Rohan LC, Kodama EN, Mitsuya H, Parniak MA, Sarafianos SG.

Structural basis of HIV inhibition by translocation defective RT inhibitor, 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA).

Proc Natl Acad Sci U S A. 113(33):9274-9. 2016.

 

Nakamura T, Campbell JR, Moore AR, Otsu S, Aikawa H, Tamamura H, Mitsuya H.

Development and validation of a cell-based assay system to assess human immunodeficiency virus type 1 integrase multimerization.

J Virol Methods. 236:196-206. 2016.

 

Endo S, Amano M, Nishimura N, Ueno N, Ueno S, Yuki H, Fujiwara S, Wada N, Hirata S, Hata H, Mitsuya H, Okuno Y.

Immunomodulatory drugs act as inhibitors of DNA methyltransferases and induce PU.1 up-regulation in myeloma cells.

Biochem Biophys Res Commun. 469(2):236-42. 2016.

 

Kumamoto H, Fukano M, Nakano T, Iwagami K, Takeyama C, Kohgo S, Imoto S, Amano M, Kuwata-Higashi N, Aoki M, Abe H, Mitsuya H, Fukuhara K, Haraguchi K.

Diastereoselective Synthesis of 6″-(Z)- and 6″-(E)-Fluoro Analogues of Anti-hepatitis B Virus Agent Entecavir and Its Evaluation of the Activity and Toxicity Profile of the Diastereomers.

J Org Chem. 81(7):2827-36. 2016.

 

Ghosh AK, Osswald HL, Glauninger K, Agniswamy J, Wang YF, Hayashi H, Aoki M, Weber IT, Mitsuya H.

Probing Lipophilic Adamantyl Group as the P1-Ligand for HIV-1 Protease Inhibitors: Design, Synthesis, Protein X-ray Structural Studies, and Biological Evaluation.

J Med Chem. 59: 6826-37. 2016.

 

Higuchi Y, Tokunaga K, Watanabe Y, Kawakita T, Harada N, Yamaguchi S, Nosaka K, Mitsuya H, Asou N.

Lineage switch with t(6;11)(q27;q23) from T-cell lymphoblastic lymphoma to acute monoblastic leukemia at relapse.

Cancer Genet. 209(6):267-71. 2016.

 

Fujiwara S, Mochinaga H, Nakata H, Ohshima K, Matsumoto M, Uchiba M, Mikami Y, Hata H, Okuno Y, Mitsuya H, Nosaka K.

Successful treatment of TAFRO syndrome, a variant type of multicentric Castleman disease with thrombotic microangiopathy with anti-IL-6 receptor antibody and steroids.

Int J Hematol. 103(6):718-23. 2016.

 

Kikukawa Y, Hata H, Ueda M, Yamashita T, Nasu S, Ide K, Ueno S, Ando Y, Mitsuya H, Okuno Y.

Successful Treatment of Amyloid Light-chain Amyloidosis in a Charcot-Marie-Tooth Disease Patient with Lenalidomide, Cyclophosphamide, and Dexamethasone.

Intern Med. 55(18):2707-12. 2016.

 

Alam M, Kuwata T, Shimura K, Yokoyama M, Ramirez Valdez KP, Tanaka K, Murata Y, Oishi S, Fujii N, Sato H, Matsuoka M, Matsushita S.

Enhanced antibody-mediated neutralization of HIV-1 variants that are resistant to fusion inhibitors.

Retrovirology. 13: 70. 2016.

 

Sugata K, Yasunaga JI, Miura M, Akari H, Utsunomiya A, Nosaka K, Watanabe Y, Suzushima H, Koh KR, Nakagawa M, Kohara M, Matsuoka M.

Enhancement of anti-STLV-1/HTLV-1 immune responses through multimodal effects of anti-CCR4 antibody.

Sci Rep. 6:27150. 2016.

 

Kuribayashi W, Takizawa K, Sugata K, Kuramitsu M, Momose H, Sasaki E, Furuhata K, Asada Y, Iwama A, Matsuoka M, Mizukami T, Hamaguchi I.

Impact of the SCF signaling pathway on leukemia stem cell-mediated ATL initiation and progression in an HBZ transgenic mouse model.

Oncotarget. In press. 2016.

 

Doi M, Murai I, Kunisue S, Setsu G, Uchio N, Tanaka R, Kobayashi S, Shimatani H, Hayashi H, Chao HW, Nakagawa Y, Hotta Y, Takahashi Y, Yasunaga JI, Matsuoka M, Hastings M, Kiyonari H, Okamura H.

Gpr176 is a Gz-linked orphan G-protein coupled receptor that sets the pace of circadian behavior.

Nat Commun. 7: 10583. 2016.

 

Kawatsuki A, Yasunaga J-I, Mitobe Y, Green PL, Matsuoka M.

HTLV-1 bZIP factor protein targets the Rb/E2F-1 pathway to promote proliferation and apoptosis of primary CD4+ T cells.

Oncogene. 35(34):4509-4517. 2016.

 

Yasuma K, Matsuzaki T, Yamano Y, Takashima H, Matsuoka M, Saito M.

HTLV-1 subgroups associated with the risk of HAM/TSP are related to viral and host gene expression in peripheral blood mononuclear cells, independent of the transactivation functions of the viral factors.

J Neurovirol. 22: 416-430. 2016.

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