世界最先端の研究で医学の発展に寄与

2015年

2015年 業績・論文

 

Haji S, Abe Y, Tsuda M, Toyoda K, Choi I, Suehiro Y, Shiratsuchi M, Kiyasu J, Uike N.

[CD20-positive plasma cell myeloma with lymphoplasmacytoid appearance mimicking low-grade B-cell lymphoma].

Rinsho Ketsueki. 56(3):335-8. 2015.

 

Mitagami Y, Yasunaga JI, Kinosada H, Ohshima K, Matsuoka M.

Interferon-g promotes inflammation and development of T-cell lymphoma in HTLV-1 bZIP factor transgenic mice.

PLoS Pathog. 11(8): e1005120. 2015.

 

Amano M, Tojo Y, Salcedo-Gómez PM, Parham GL, Nyalapatla PR, Das D, Ghosh AK, Mitsuya H.

A Novel Tricyclic Ligand-Containing Nonpeptidic HIV-1 Protease Inhibitor, GRL-0739, Effectively Inhibits the Replication of Multidrug-Resistant HIV-1 Variants and Has a Desirable Central Nervous System Penetration Property In Vitro.  

Antimicrob Agents Chemother. 59(5):2625-35. 2015.

 

Fujiwara S, Wada N, Kawano Y, Okuno Y, Kikukawa Y, Endo S, Nishimura N, Ueno N, Mitsuya H, Hata H.

Lactate, a putative survival factor for myeloma cells, is incorporated by myeloma cells through monocarboxylate transporters 1.

Exp Hematol Oncol. 4:12. 2015.

 

Wada N, Kawano Y, Fujiwara S, Kikukawa Y, Okuno Y, Tasaki M, Ueda M, Ando Y, Yoshinaga K, Ri M, Iida S, Nakashima T, Shiotsu Y, Mitsuya H, Hata H.

Shikonin, dually functions as a proteasome inhibitor and a necroptosis inducer in multiple myeloma cells.

Int J Oncol. 46(3):963-72. 2015.

 

Takamatsu Y, Tanaka Y, Kohgo S, Murakami S, Singh K, Das D, Venzon DJ, Amano M, Higashi-Kuwata N, Aoki M, Delino NS, Hayashi S, Takahashi S, Sukenaga Y, Haraguchi K, Sarafianos SG, Maeda K, Mitsuya H.

4'-Modified Nucleoside Analogs: Potent Inhibitors Active against Entecavir-Resistant Hepatitis B Virus.

Hepatology. 62(4):1024-36. 2015.

 

Sugata K, Yasunaga JI, Mitobe Y, Miura M, Miyazato P, Kohara M, Matsuoka M.

Protective effect of cytotoxic T lymphocytes targeting HTLV-1 bZIP factor.

Blood. 126: 1095-105. 2015.

 

Ghosh AK, Martyr CD, Kassekert LA, Nyalapatla PR, Steffey M, Agniswamy J,Wang YF, Weber IT, Amano M, Mitsuya H.

Design, synthesis, biological evaluation and X-ray structural studies of HIV-1 protease inhibitors containing substituted fused-tetrahydropyranyl tetrahydrofuran as P2-ligands.

Org Biomol Chem. 13(48):11607-21. 2015.

 

Ghosh AK, Martyr CD, Osswald HL, Sheri VR, Kassekert LA, Chen S, Agniswamy J, Wang YF, Hayashi H, Aoki M, Weber IT, Mitsuya H.

Design of HIV-1 Protease Inhibitors with Amino-bis-tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation, and Protein-Ligand X-ray Studies.

J Med Chem. 58(17):6994-7006. 2015.

 

Imoto S, Kohgo S, Tokuda R, Kumamoto H, Aoki M, Amano M, Kuwata-Higashi N, Mitsuya H, Haraguchi K.

Design, Synthesis, and Evaluation of Anti-HBV Activity of Hybrid Molecules of Entecavir and Adefovir: Exomethylene Acycloguanine Nucleosides and Their Monophosphate Derivatives.

Nucleosides Nucleotides Nucleic Acids. 34(8):590-602. 2015.

 

Ghosh AK, Yu X, Osswald HL, Agniswamy J, Wang YF, Amano M, Weber IT, Mitsuya H.

Structure-Based Design of Potent HIV-1 Protease Inhibitors with Modified P1-Biphenyl Ligands: Synthesis, Biological Evaluation, and Enzyme-Inhibitor X-ray Structural Studies.

J Med Chem. 58(13):5334-43. 2015.

 

Ghosh AK, Takayama J, Kassekert LA, Ella-Menye JR, Yashchuk S, Agniswamy J, Wang YF, Aoki M, Amano M, Weber IT, Mitsuya H.

Structure-Based Design, Synthesis, X-ray Studies, and Biological Evaluation of Novel HIV-1 Protease Inhibitors containing Isophthalamide-Derived P2-Ligands.

Bioorg Med Chem Lett. 25(21):4903-9. 2015.

 

Aoki M, Hayashi H, Yedidi RS, Martyr CD, Takamatsu Y, Aoki-Ogata H, Nakamura T, Nakata H, Das D, Yamagata Y, Ghosh AK, Mitsuya H.

C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir.

J Virol. 90(5):2180-94. 2015.

 

Kikukawa Y, Yuki H, Hirata S, Ide K, Nakata H, Miyakawa T, Matsuno N, Nosaka K, Yonemura Y, Kawaguchi T, Hata H, Mitsuya H, Okuno Y.

Combined use of bortezomib, cyclophosphamide, and dexamethasone induces favorable hematological and organ responses in Japanese patients with amyloid light-chain amyloidosis: a single-institution retrospective study.

Int J Hematol. 101(2):133-9. 2015.

 

Das D, Maeda K, Hayashi Y, Gavande N, Desai DV, Chang SB, Ghosh AK, Mitsuya H.

Insights into the Mechanism of Inhibition of CXCR4: Identification of Piperidinylethanamine Analogs as Anti-HIV-1 Inhibitors.

Antimicrob Agents Chemother. 59(4):1895-904. 2015.

 

Hirano T, Higuchi Y, Yuki H, Hirata S, Nosaka K, Ishii N, Hashimoto T, Mitsuya H, Okuno Y.

Rituximab Monotherapy and Rituximab-Containing Chemotherapy were Effective for Paraneoplastic Pemphigus Accompanying Follicular Lymphoma, but not for Subsequent Bronchiolitis Obliterans.

J Clin Exp Hematop. 55(2):83-8. 2015

 

Kikukawa Y, Yamamura-Fujimoto A, Endo S, Miyagawa E, Kawano Y, Ueno S, Mitsuya H, Hata H, Okuno Y.

Successful Treatment of Bing-Neel Syndrome accompanying Waldenström's Macroglobulinemia with R-MPV: A Case Report.

J Clin Exp Hematop. 55(2):113-9. 2015.

 

Mitobe Y, Yasunaga JI, Furuta R, Matsuoka M.

HTLV-1 bZIP factor (HBZ) RNA and protein impart distinct functions on T cell proliferation and survival.

Cancer Res. 75: 4143-52. 2015.

 

Kataoka K, Nagata Y, Kitanaka A, Shiraishi Y, Shimamura T, Yasunaga J, Totoki Y, Chiba K, Sato-Otsubo A, Nagae G, Ishii R, Kotani S, Watatani Y, Takeda J, Sanada M, Tanaka H, Suzuki H, Sato Y, Shiozawa Y, Yoshizato T, Yoshida K, Makishima H, Iwanaga M, Ma G, Nosaka K, Hishizawa M, Itonaga H, Imaizumi Y, Munakata W, Ogasawara H, Sato T, Sasai K Muramoto K, Penova M, Kawaguchi T, Nakamura H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda T, Nakamaki T, Ishiyama K, Miyawaki S, Yoon S, Tobinai K, Miyazaki Y, Takaori-Kondo A, Matsuda F, Takeuchi K, Nureki O, Aburatani H, Watanabe T, Shibata T, Matsuoka M, Miyano S, Shimoda K, Ogawa S.

Integrated molecular analysis of adult T-cell leukemia/lymphoma.

Nat Genet. 47: 1304-15. 2015.

 

Sato K, Kobayashi T, Misawa N, Yoshikawa R, Takeuchi JS, Miura T, Okamoto M, Yasunaga JI, Matsuoka M, Ito M, Miyazawa T, Koyanagi Y.

Experimental evaluation of the zoonotic infection potency of simian retrovirus type 4 using humanized mouse model.

Sci Rep. 5:14040, 2015.

 

Shimura K, Miyazato P, Oishi S, Fujii N, Matsuoka M.

Impact of HIV-1 infection pathways on susceptibility to antiviral drugs and on virus spread.

Virology. 484:364-376. 2015.

 

Ma G, Yasunaga J-I, Akari H, Matsuoka M.

TCF1 and LEF1 act as T-cell intrinsic HTLV-1 antagonists by targeting Tax.

Proc. Natl. Acad. Sci. USA. 112: 2216-21. 2015.

 

Okazaki S, Oishi S, Mizuhara T, Shimura K, Murayama H, Ohno H, Matsuoka M, Fujii N.

Investigations of possible prodrug structures for 2-(2-mercaptophenyl) tetrahydropyrimidines: reductive conversion from anti-HIV agents with pyrimidobenzothiazine and isothiazolopyrimidine scaffolds.

Org Biomol Chem. 13: 4706-13. 2015.

 

Takachi T, Takahashi M, Takahashi-Yoshita M, Higuchi M, Obata M, Mishima Y, Okuda S, Tanaka Y, Matsuoka M, Saitoh A, Green P, Fujii M.

Human T-cell leukemia virus type 1 Tax oncoprotein represses the expression of the BCL11B tumor suppressor in T-cells.

Cancer Sci. 106: 461-5. 2015.

 

Kinpara S, Ito S, Takahata T, Saitoh Y, Hasegawa A, Kijiyama M, Utsunomiya A, Masuda M, Miyazaki Y, Matsuoka M, Nakamura M, Yamaoka S, Masuda T, Kannagi M.

Involvement of double-stranded RNA-dependent protein kinase and anti-sense viral RNA in the constitutive NFκB activation in adult T-cell leukemia/lymphoma cells.

Leukemia. 29: 1425-44. 2015.

 

Suehiro Y, Hasegawa A, Iino T, Sasada A, Watanabe N, Matsuoka M, Takamori A, Tanosaki R, Utsunomiya A, Choi I, Fukuda T, Miura O, Takaishi S, Teshima T, Akashi K, Kannagi M, Uike N, Okamura J.

Clinical outcomes of a novel therapeutic vaccine with Tax peptide-pulsed dendritic cells for adult T-cell leukemia/lymphoma in a pilot study.

Br J Haematol. 169: 356-67. 2015.

 

Okazaki S, Mizuhara T, Shimura K, Murayama H, Ohno H, Oishi S, Matsuoka M, Fujii N.

Identification of anti-HIV agents with a novel benzo [4,5]isothiazolo [2,3-a]pyrimidine scaffold.

Bioorg & Med Chem. 23: 1447-52. 2015.

 

Furuta RA, Ma G, Matsuoka M, Otani S, Matsukura H, Hirayama F.

Re-evaluation of screening of plasma positive for human T-cell leukemia virus type 1 using a luciferase immunoprecipitation system in blood donors.

Transfusion. 55: 880-889. 2015.

 

Ghosh AK, Yashchuk S, Mizuno A, Chakraborty N, Agniswamy J, Wang YF, Aoki M, Gomez PM, Amano M, Weber IT, Mitsuya H.

Design of gem-difluoro-bis-tetrahydrofuran as P2 ligand for HIV-1 protease inhibitors to improve brain penetration: synthesis, X-ray studies, and biological evaluation.

ChemMedChem. 10(1):107-15. 2015.

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